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首页> 外文期刊>Clinical and experimental allergy : >The A to E of airway disease.
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The A to E of airway disease.

机译：气道疾病的A到E。

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The terms asthma and chronic obstructive pulmonary disease have evolved from their original very specific physiology-based definition to describe additional disease entities such as symptoms, airway inflammation and airway structure. We argue that as a result there is widespread confusion about what the terms mean. This has become a significant hurdle to optimal disease management and drug development. We propose that these disease labels should be replaced with a new alphabetical assessment tool for characterizing airway disease, which provides a checklist of five relatively independent factors potentially responsible for morbidity in patients with airway disease: Airway hyperresponsiveness, Bronchitis, Cough reflex hypersensitivity, Damage to the airway and surrounding lung and Extrapulmonary factors. We speculate that the use of this system to characterize airway disease will improve outcomes by promoting better targeting of new and existing treatments.
机译：术语哮喘和慢性阻塞性肺疾病已经从其最初的非常特定的基于生理的定义演变而来，用于描述其他疾病，例如症状，气道炎症和气道结构。我们认为，结果是人们对这些术语的含义普遍感到困惑。这已成为优化疾病管理和药物开发的重要障碍。我们建议将这些疾病标签替换为表征气道疾病的新字母评估工具，该工具提供清单，列出可能与气道疾病患者发病有关的五个相对独立的因素：气道高反应性，支气管炎，咳嗽反射超敏反应，气道及周围肺与肺外因素。我们推测使用该系统表征气道疾病将通过促进更好地针对新疗法和现有疗法来改善预后。

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