Pseurotin A and its analogues as inhibitors of immunoglobuline E production.

Ishikawa M; Ninomiya T; Akabane H; Kushida N; Tsujiuchi G; Ohyama M; Gomi S; Shito K; Murata T

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Pseurotin A and its analogues as inhibitors of immunoglobuline E production.

机译：伪神经素A及其类似物作为免疫球蛋白E产生的抑制剂。

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A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.

机译：天然的伪神经素A在体外抑制IgE的产生。进行了伪神经素A的多种化学修饰。伪嘌呤类似物的结构活性关系研究表明，10-脱氧pseurotinin A强烈抑制IgE的产生，IC（50）为0.066 microM。还发现了另一种天然产物Synerazol的免疫抑制活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2009年第5期|共4页
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Ishikawa M; Ninomiya T; Akabane H; Kushida N; Tsujiuchi G; Ohyama M; Gomi S; Shito K; Murata T;
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1. Pseurotin A and its analogues as inhibitors of immunoglobuline E production. [J] . Ishikawa M, Ninomiya T, Akabane H, Bioorganic and Medicinal Chemistry Letters . 2009,第5期

机译：伪神经素A及其类似物作为免疫球蛋白E产生的抑制剂。
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Pseurotin A and its analogues as inhibitors of immunoglobuline E production.

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