Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.

Morita H; Deguchi J; Motegi

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.

【24h】

Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.

机译：环状二芳基庚烷类化合物，作为Acer nikoense的Na +-葡萄糖共转运蛋白（SGLT）抑制剂。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two cyclic diarylheptanoids, acerogenins A (1) and B (2) have been isolated from the bark of Acer nikoense as inhibitors of Na(+)-glucose cotransporter (SGLT). Acerogenins A (1) and B (2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed.

机译：两个环二芳基庚烷类，acerogenins A（1）和B（2）已从Acer nikoense的树皮中分离出来，作为Na（+）-葡萄糖共转运蛋白（SGLT）的抑制剂。 Acerogenins A（1）和B（2）抑制SGLT1和SGLT2这两种同工型。讨论了铜绿皂苷元衍生物对SGLT抑制活性的构效关系，并基于J-解析的HMBC光谱和X射线分析对1和2进行构象分析。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2010年第3期|共5页
作者
Morita H; Deguchi J; Motegi;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. [J] . Morita H, Deguchi J, Motegi Bioorganic and Medicinal Chemistry Letters . 2010,第3期

机译：环状二芳基庚烷类化合物，作为Acer nikoense的Na +-葡萄糖共转运蛋白（SGLT）抑制剂。
2. Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. [J] . Yonezawa T, Lee JW, Akazawa H, Bioorganic and Medicinal Chemistry Letters . 2011,第11期

机译：源自Acer nikoense的二苯醚型环状二芳基庚烷的成骨活性。
3. Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. [J] . Yonezawa T, Lee JW, Akazawa H, Bioorganic and Medicinal Chemistry Letters . 2011,第11期

机译：源自Acer nikoense的二苯醚型环状二芳基庚烷的成骨活性。
4. Polymer-Phloridzin Conjugates as an Anti-diabetic Drug that Inhibits Glucose Absorption through the Na~+/Glucose Cotransporter (SGLT1) in the Small Intestine [C] . Y. Ikumi, T. Kida, S. Sakuma, Controlled Release Society Annual Meeting and Exposition . 2007

机译：高分子磷脂结合作为一种抑制糖尿病的药物，通过小肠中的Na〜+ /葡萄糖共转运蛋白（SGLT1）抑制葡萄糖吸收。
5. Getting to the Heart of the Matter: Clinical Inertia Slows SGLT2 Inhibitor Prescribing Rates in Patients with T2D and Concurrent ASCVD [D] . Scott, Joshua Seth. 2019

机译：达到此事的核心：临床惯性减缓了T2D和同时ASCVD患者的SGLT2抑制剂处方率
6. Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit [O] . T Zeuthen, A-K Meinild, D D F Loo, 2001

机译：Na +-葡萄糖共转运蛋白SGLT1从人和兔的等渗转运
7. Studies on the Constituents of Aceraceae Plants. XI. Two Types of Cyclic Diarylheptanoid from Acer nikoense. [O] . Seiji NAGUMO, Norihiro KAJI, Takao INOUE, 1993

机译：植物植物成分研究。 XI。来自宏碁Nikoense的两种类型的循环二芳基肽。

Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.

摘要

著录项

相似文献

相关主题

期刊订阅