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首页> 外文期刊>Brain research >Hypothalamic monoamine metabolism is different between the diabetic GK (Goto-Kakizaki) rats and streptozotocin-induced diabetic rats.
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Hypothalamic monoamine metabolism is different between the diabetic GK (Goto-Kakizaki) rats and streptozotocin-induced diabetic rats.

机译：下丘脑单胺代谢在糖尿病GK（Goto-Kakizaki）大鼠和链脲佐菌素诱导的糖尿病大鼠之间是不同的。

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摘要

Hypothalamic neuronal activities of noradrenaline, dopamine and serotonin were investigated in the GK (Goto-Kakizaki) rats, a model for type 2 diabetes, and the streptozotocin (STZ)-induced diabetic rats, a model for type 1 diabetes. Each neuronal activity was assessed from a ratio of the concentrations of the major metabolite to those of its precursor monoamine itself or the metabolite concentrations itself. In the GK rats, hypothalamic noradrenaline and dopamine activities were significantly increased, and serotonin activity was unchanged. In the STZ-induced diabetic rats, hypothalamic dopamine and serotonin activities were significantly decreased, and noradrenaline activity was unchanged. In these two diabetic rats, hypothalamic noradrenaline and dopamine activities correlated significantly with serum insulin concentrations, whereas hypothalamic serotonin activity correlated significantly with serum glucose concentrations. These findings suggest that hypothalamic monoamine metabolism of the GK rats is quite different from that of the STZ-induced diabetic rats, and that not only hyperglycemia but also serum insulin concentrations have an influence on the hypothalamic monoamine metabolism in these diabetic rats.
机译：在2型糖尿病模型GK（Goto-Kakizaki）大鼠和链脲佐菌素（STZ）诱导的1型糖尿病模型糖尿病大鼠中研究了去甲肾上腺素，多巴胺和5-羟色胺的下丘脑神经元活性。从主要代谢物浓度与其前体单胺本身或代谢物浓度本身之比来评估每种神经元活性。在GK大鼠中，下丘脑去甲肾上腺素和多巴胺活性显着增加，而血清素活性未改变。在STZ诱导的糖尿病大鼠中，下丘脑多巴胺和血清素活性明显降低，去甲肾上腺素活性未改变。在这两只糖尿病大鼠中，下丘脑去甲肾上腺素和多巴胺的活性与血清胰岛素浓度显着相关，而下丘脑的血清素活性与血清葡萄糖浓度显着相关。这些发现表明，GK大鼠的下丘脑单胺代谢与STZ诱导的糖尿病大鼠完全不同，并且不仅高血糖症而且血清胰岛素浓度也对这些糖尿病大鼠的下丘脑单胺代谢产生影响。

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