...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Functional imaging of semantic memory predicts postoperative episodic memory functions in chronic temporal lobe epilepsy.
【24h】

Functional imaging of semantic memory predicts postoperative episodic memory functions in chronic temporal lobe epilepsy.

机译：语义记忆的功能成像可预测慢性颞叶癫痫术后的情景记忆功能。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Medial temporal (MTL) structures have crucial functions in episodic (EM), but also in semantic memory (SM) processing. Preoperative functional magnetic resonance imaging (fMRI) activity within the MTL is increasingly used to predict post-surgical memory capacities. Based on the hypothesis that EM and SM memory functions are both hosted by the MTL the present study wanted to explore the relationship between SM related activations in the MTL as assessed before and the capacity of EM functions after surgery. Patients with chronic unilateral left (n=14) and right (n=12) temporal lobe epilepsy (TLE) performed a standard word list learning test pre- and postoperatively, and a fMRI procedure before the operation using a semantic decision task. SM processing caused significant bilateral MTL activations in both patient groups. While right TLE patients showed asymmetry of fMRI activation with more activation in the left MTL, left TLE patients had almost equal activation in both MTL regions. Contrasting left TLE versus right TLE patients revealed greater activity within the right MTL, whereas no significant difference was observed for the reverse contrast. Greater effect size in the MTL region ipsilateral to the seizure focus was significantly and positively correlated with preoperative EM abilities. Greater effect size in the contralateral MTL was correlated with better postoperative verbal EM, especially in left TLE patients. These results suggest that functional imaging of SM tasks may be useful to predict postoperative verbal memory in TLE. They also advocate a common neuroanatomical basis for SM and EM processes in the MTL.
机译：中间时态（MTL）结构在情节（EM）以及语义记忆（SM）处理中具有关键功能。 MTL中的术前功能性磁共振成像（fMRI）活动越来越多地用于预测手术后的记忆能力。基于EM和SM记忆功能均由MTL承担的假设，本研究希望探讨MTL中SM相关激活（如之前评估）与手术后EM功能的能力之间的关系。患有慢性单侧左侧（n = 14）和右侧（n = 12）颞叶癫痫（TLE）的患者在术前和术后进行了标准单词列表学习测试，并在手术前使用了语义决策任务进行了功能磁共振成像检查。 SM处理在两个患者组中均引起了明显的双边MTL激活。右TLE患者显示fMRI激活不对称，而左MTL具有更多激活，而左TLE患者在两个MTL区域均具有几乎相同的激活。左TLE与右TLE患者的对比显示，右MTL内的活性更高，而反向对比没有观察到显着差异。癫痫病灶同侧的MTL区域更大的疗效与术前EM能力显着正相关。对侧MTL的更大疗效与术后更好的言语EM相关，尤其是在左TLE患者中。这些结果表明，SM任务的功能成像可能有助于预测TLE的术后言语记忆。他们还主张在MTL中为SM和EM过程提供通用的神经解剖学基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号