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首页> 外文期刊>Brain research >Effects of sex steroids and estrogen receptor agonists on the expression of estrogen receptor alpha in the principal division of the bed nucleus of the stria terminalis of female rats
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Effects of sex steroids and estrogen receptor agonists on the expression of estrogen receptor alpha in the principal division of the bed nucleus of the stria terminalis of female rats

机译：性类固醇和雌激素受体激动剂对雌性大鼠终末期纹状体床核主分裂中雌激素受体α表达的影响

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Estrogen actions on neurons of the principal division of the bed nucleus of the stria terminalis (BNSTpr) are essential for the regulation of female sexual behavior. However, little is known about the effects of estradiol and progesterone (P) on estrogen receptor alpha (ERa) expression in this nucleus. To study this subject, we used stereological methods to estimate the total number of ERcc-immunoreactive (ERa-ir) neurons in the BNSTpr of female rats at each stage of the estrous cycle and of ovariectomized rats after administration of estradiol benzoate (EB) and/or P. To ascertain the percentage of ERa-positive neurons in the BNSTpr, the total number of neurons in this nucleus was also estimated. In order to identify the specific role played by the selective activation of each ER in the expression of ERa, ovariectomized rats were injected with the ERa agonist, propyl-pyrazole triol (PPT), or the ER(3 agonist, diaryl-propionitrile (DPN). Data show that ERa is expressed in 40-60% of the BNSTpr neurons and that the number of ERa-ir neurons is lowest at proestrus. This value is paralleled by the administration of EB. The number of ERa-ir neurons was not modified by P. PPT induced no changes in the number of ERa-ir neurons. Contrariwise, DPN induced a decrease in the total number of ERa-ir neurons to values similar to those of EB-treated rats. These results show that P has no effect in the modulation of ERa expression and demonstrate that estradiol regulation of ERa in BNSTpr neurons is mediated by activation of ERp.
机译：雌激素对终末皮层床核主要部分的神经元的神经元作用（BNSTpr）对于调节女性的性行为至关重要。然而，关于该细胞核中雌二醇和孕酮（P）对雌激素受体α（ERa）表达的影响知之甚少。为了研究这一主题，我们使用了立体学方法来估计雌性大鼠在发情周期的每个阶段的BNSTpr中的雌激素免疫反应（ERa-ir）神经元的数量，以及在雌二醇苯甲酸酯（EB）和为了确定BNSTpr中ERa阳性神经元的百分比，还估算了该核中神经元的总数。为了确定每个ER在ERa表达中的选择性激活所起的特定作用，给卵巢切除的大鼠注射ERa激动剂，丙基吡唑三醇（PPT）或ER（3激动剂，二芳基丙腈（DPN） ）。数据显示，ERa在40％至60％的BNSTpr神经元中表达，并且在发情期，ERa-ir神经元的数量最低，该值与EB给药平行，而ERa-ir神经元的数量却没有PPT修饰后的PPT不会引起ERa-ir神经元数量的变化，相反，DPN诱导的ERa-ir神经元总数减少，其值与EB处理的大鼠相似。在调节ERa表达中发挥作用，证明BNSTpr神经元中ERa的雌二醇调节是由ERp的激活介导的。

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