• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Brain source localization of MMN, P300 and N400: Aging and gender differences
【24h】

Brain source localization of MMN, P300 and N400: Aging and gender differences

机译：MMN，P300和N400的脑源定位：老龄化和性别差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The localization of neuronal generators during an ERP study, using a high-density electroencephalogram (HD-EEG) equipment was made on three Evoked Related Potential (ERP) components, i.e., the Mismatch Negativity (MMN), the P300 and the N400. Furthermore, the ERP characteristics, their field distribution and the area of their maximum field intensity were extracted and compared between young and elderly, as well as between females and males. A two tone oddball experiment was conducted, involving 27 young adults and 18 elderly, healthy and right handed, and HD-EEG data were acquired. These data were then subjected to auditory ERPs extraction and thorough statistical analysis. The derived experimental results revealed significant age-related differences to both the latencies and the amplitudes of the MMN and the P300 and the topographic distribution of the HD-EEG amplitudes. Additionally, a shift in the maximum intensities from frontal to temporal lobe with aging appeared in the case of the P300, whereas no effect was observed for the MMN component. No statistical significant differences (p > 0.05) due to age was found in N400 characteristics. Finally, gender-related differences were significant in the response time of the subjects, finding males response faster. The level and the location of the maximum intensity of sources also differed between genders, especially in young subjects. These findings justify the enhanced potential of HD-EEG data to accurately reflect the age and gender dependencies at the three components of simple auditory ERPs and pave the way for the investigation of neurodegenerative pathologies, such as the Alzheimer's disease. (C) 2014 Elsevier B.V. All rights reserved.
机译：在ERP研究期间，使用高密度脑电图（HD-EEG）设备对神经诱发源进行了定位，该设备是在三个诱发相关电位（ERP）组件上进行的，即失配负电位（MMN），P300和N400。此外，还提取并比较了年轻人和老年人之间以及女性和男性之间的ERP特征，其场分布和最大场强度区域。进行了两音奇异球实验，涉及27位年轻人和18位年老，健康且右手的人，并获取了HD-EEG数据。然后对这些数据进行听觉ERP提取和全面的统计分析。得出的实验结果表明，MMN和P300的延迟和幅度以及HD-EEG幅度的地形分布都存在明显的年龄相关差异。另外，在P300的情况下，随着年龄的增长，最大强度从额叶转移到颞叶，而MMN组件未见效果。在N400特征中，未发现由于年龄引起的统计学显着差异（p> 0.05）。最后，与性别相关的差异在受试者的反应时间上很明显，发现男性反应更快。性别的最大强度水平和位置也有所不同，尤其是在年轻受试者中。这些发现证明，HD-EEG数据具有增强的潜力，可以准确反映简单听觉ERP的三个组成部分中的年龄和性别依赖性，并为研究神经退行性病变（例如阿尔茨海默氏病）铺平了道路。 （C）2014 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号