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首页> 外文期刊>Brain research >Biostimulation and nursing modify mating-induced c-FOS immunoreactivity in the female rabbit forebrain
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Biostimulation and nursing modify mating-induced c-FOS immunoreactivity in the female rabbit forebrain

机译：生物刺激和护理可改善雌性兔前脑中交配诱导的c-FOS免疫反应性

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摘要

Mating in rabbits lasts only 3-5 s but profoundly changes the female's physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after suppressing a single nursing bout ("biostimulation"). Little is known about the mechanisms mediating the differential responsiveness to mating among estrous, lactating, and biostimulated rabbits. To begin addressing this issue we quantified the number of c-FOS-immunoreactive (IR) cells in the preoptic area (POA), dorsomedial hypothalamus (DMH), ventromedial hypothalamus (VMH), infundibular nucleus (INF), paraventricular nucleus (PVN), supraoptic nucleus (SON), and lateral septum (LS) in mated and unmated does from the above three reproductive conditions. Mating increased c-FOS-IR cells in the POA and PVN relative to unmated estrous does. Biostimulation increased c-FOS-IR cells in the PVN, relative to lactating does, regardless of mating. Lactation reduced the responsiveness of the LS and INF to copulation but increased it in the DMH. No differences were found in the VMH. Conclusions: a) copulation activates forebrain nuclei that regulate scent-marking (POA), ovulation (INF), and post-coital oxytocin release (PVN); b) lactation and suppression of one nursing bout modulate the magnitude of such changes. (C) 2015 Elsevier B.V. All rights reserved.
机译：兔子的交配仅持续3-5秒，但会极大地改变雌性的生理和行为（例如，抑制气味标记和行走功能，EEG的变化以及GnRH的释放）。相对于发情，在哺乳期兔子中对交配的行为反应性有所降低，但在抑制了一次哺乳后就增强了（“生物刺激”）。关于在发情，泌乳和生物刺激的兔子之间介导对交配的差异反应的机制知之甚少。为了开始解决这个问题，我们量化了视前区（POA），下丘脑下丘脑（DMH），下丘脑下丘脑（VMH），漏斗状核（INF），脑室旁核（PVN）的c-FOS免疫反应（IR）细胞的数量以上三种生殖条件下，交配和未交配的视，上视核（SON）和外侧隔（LS）的情况。相对于未交配的发情，在POA和PVN中交配增加的c-FOS-IR细胞。相对于哺乳期，无论交配，生物刺激都会增加PVN中c-FOS-IR细胞的数量。泌乳降低了LS和INF对交配的反应，但在DMH中却增加了。在VMH中未发现差异。结论：a）交配激活前脑核，从而调节气味标记（POA），排卵（INF）和性交催产素释放（PVN）; b）哺乳和抑制一次哺乳会改变这种变化的幅度。 （C）2015 Elsevier B.V.保留所有权利。

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