Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats

Wang Yaxuan; Cao Xuezhao; Ma Hong; Tan Wenfei; Zhang Lingwei; Li Zhe; Gao Yalei

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Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats

机译：先前的应激源暴露会延缓老年大鼠因手术引起的认知障碍的恢复并延长神经炎症

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Increasing evidence indicates that stress potentiates pro-inflammatory response to a subsequent peripheral immune challenge. The present study investigated if prior exposure to inescapable tailshock (IS) delayed the recovery of surgery-induced spatial learning and memory impairment and prolonged hippocampus interleukin (IL)-1 beta and IL-6 expression.

机译：越来越多的证据表明，压力增强了对随后的外周免疫挑战的促炎反应。本研究调查了先前暴露于不可避免的休克（IS）是否延迟了手术引起的空间学习和记忆障碍以及海马白介素（IL）-1β和IL-6表达延长的恢复。

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《Brain research》 |2016年第null期|共7页
作者
Wang Yaxuan; Cao Xuezhao; Ma Hong; Tan Wenfei; Zhang Lingwei; Li Zhe; Gao Yalei;
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正文语种 eng
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Postoperative cognitive dysfunction (POCD); Prior stress; Inescapable tailshock (IS); Neuroinflammation; Hippocampus; Aging;

机译：术后认知功能障碍（POCD）;压力过大;不可避免的休克（IS）;神经炎症;海马体;衰老;

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1. Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats [J] . Wang Yaxuan, Cao Xuezhao, Ma Hong, Brain research . 2016,第Null期

机译：先前的压力源暴露延迟了手术引起的认知障碍的恢复，延长了老年大鼠的神经炎症
2. Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4 [J] . Li Zhe, Liu Fang, Ma Hong, Brain research . 2017,第期

机译：年龄加剧了Sprague-Dawley大鼠的手术引起的认知障碍和神经炎症：IL-4的作用
3. Exposure to As-, Cd-, and Pb-Mixture Induces A beta, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats [J] . Ashok Anushruti, Rai Nagendra Kumar, Tripathi Sachin, Toxicological sciences: An official journal of the Society of Toxicology . 2015,第1期

机译：暴露于As，Cd和Pb混合物可诱发年轻大鼠的Aβ，淀粉样蛋白APP处理和氧化应激依赖性神经炎症引起的认知障碍。
4. Effect of chronic RF-EMF exposure on aging-induced oxidative stress and neuroinflammation in C57BL/6 mice [C] . Ye Ji Jeong, Hyung-Do Choi, Jeong-Ki Pack, Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association . 2018

机译：慢性RF-EMF暴露对C57BL / 6小鼠衰老氧化应激和神经炎症的影响
5. Neuroinflammation and cognitive impairment in the aged: Implications for nutritional intervention. [D] . Abraham, Jayne. 2009

机译：老年人的神经炎症和认知障碍：对营养干预的意义。
6. Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats [O] . PENG JIANG, QIONG LING, HONGBO LIU, -1

机译：颅内注射白细胞介素6受体拮抗剂通过抑制老龄大鼠的神经炎症反应减轻手术引起的认知障碍
7. Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats [O] . Wang Yaxuan, Cao Xuezhao, Ma Hong, 2016

机译：先前的应激源暴露会延缓老年大鼠因手术引起的认知障碍的恢复并延长神经炎症

Prior stressor exposure delays the recovery of surgery-induced cognitive impairment and prolongs neuroinflammation in aged rats

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