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首页> 外文期刊>Brain research >Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat
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Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat

机译：暴露于极低频电磁场中对大鼠海马长时程增强的影响

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摘要

Modem lifestyle exposes nearly all humans to electromagnetic fields, particularly to extremely low frequency electromagnetic fields (ELF-EMFs). Prolonged exposure to ELF-EMFs induces persistent changes in neuronal activity. However, the modulation of synaptic efficiency by ELF-EMFs in vivo is still unclear. In the present study, we investigated whether ELF-EMFs can change induction of long-term potentiation (LTP) and paired-pulse ratio (PPR) in the rat hippocampal area. Twenty-nine adult male Wistar rats were divided into 3 groups (ELF-EMF exposed, sham and control groups). The ELF-EMF group was exposed to a magnetic field for 90 consecutive days (2 h/day). ELF-EMFs were produced by a circular coil (50 Hz, 100 micro Tesla). The sham-exposed controls were placed in an identical chamber with no electromagnetic field. After this period, rats were deeply anesthetized with urethane (2.0 mg/kg) and then a bipolar stimulating and recording electrode was implanted into the perforant pathway (PP) and dentate gyrus (DG), respectively. LTP in hippocampal area was induced by high-frequency stimulation (HFS). Prolonged exposure to ELF-EMFs increased LTP induction. There was a significant difference in the slope of EPSP and amplitude of PS between the ELF-EMF group and other groups. In conclusion, our data suggest that exposure to ELF-EMFs produces a marked change in the synaptic plasticity generated in synapses of the PP-DG. No significant difference in PPR of ELF-EMF group before and after HFS suggests a postsynaptic expression site of LTP.
机译：现代生活方式几乎将所有人暴露在电磁场中，特别是极低频电磁场（ELF-EMF）。长时间暴露于ELF-EMFs会引起神经元活动的持续变化。但是，尚不清楚在体内ELF-EMF对突触效率的调节。在本研究中，我们调查了ELF-EMFs是否可以改变大鼠海马区的长时程增强（LTP）和配对脉冲比（PPR）的诱导。将29只成年雄性Wistar大鼠分为3组（暴露于ELF-EMF的大鼠，假手术和对照组）。 ELF-EMF组连续90天（2小时/天）暴露于磁场。 ELF-EMF由圆形线圈（50 Hz，100 micro Tesla）制成。将假接触的对照放置在没有电磁场的相同室内。在此期间之后，将大鼠用2.0毫克/千克的尿烷深度麻醉，然后将双极刺激和记录电极分别植入穿孔通路（PP）和齿状回（DG）中。海马区的LTP是由高频刺激（HFS）诱导的。长时间暴露于ELF-EMF会增加LTP诱导。 ELF-EMF组与其他组之间的EPSP斜率和PS振幅存在显着差异。总之，我们的数据表明，暴露于ELF-EMF会使PP-DG的突触产生的突触可塑性发生明显变化。 HFS前后ELF-EMF组的PPR无明显差异，提示LTP的突触后表达位点。

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