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首页> 外文期刊>Chemistry: A European journal >Multifunctional manganese carbonate microspheres with superparamagnetic and fluorescent properties: Synthesis and biological application
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Multifunctional manganese carbonate microspheres with superparamagnetic and fluorescent properties: Synthesis and biological application

机译：具有超顺磁性和荧光特性的多功能碳酸锰微球：合成与生物学应用

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摘要

Multifunctional manganese carbonate microspheres with superparamagnetic and fluorescent properties were fabricated and used as biological labels. The Fe_3O_4@MnCO_3 microspheres were synthesized by direct co-precipitation without any linker shell. The Fe_3O _4@MnCO_3 microspheres have uniform size distribution and rough surface, which provides a promising template for the assembly of polyelectrolytes (PEs) and CdTe quantum dots (QDs). A luminescent CdTe shell was observed in Fe_3O_4@MnCO_3@PE-CdTe spheres by confocal fluorescence imaging. With excellent solubility in water and rough surfaces, the multifunctional microsphere offers a friendly microenvironment for immobilization of α-fetoprotein (AFP) antibodies (Ab_2) to fabricate Fe_3O_4@MnCO_3@PE-CdTe-Ab_2 architecture. By using the Fe_3O_4@MnCO_3@PEs- CdTe-Ab_2 bioconjugate as a label, a promising and versatile platform for fluorescence imaging and electrochemical immunosensing of cancer biomarker AFP was developed. The prepared electrochemical immunosensor shows high sensitivity and selectivity with a detection limit of 0.3 pg mL~(-1).
机译：制备了具有超顺磁性和荧光性质的多功能碳酸锰微球，并将其用作生物标记。 Fe_3O_4 @ MnCO_3微球是通过直接共沉淀法合成的，没有任何连接子壳。 Fe_3O _4 @ MnCO_3微球具有均匀的尺寸分布和粗糙的表面，这为聚电解质（PE）和CdTe量子点（QD）的组装提供了有希望的模板。通过共聚焦荧光成像在Fe_3O_4 @ MnCO_3 @ PE-CdTe球体中观察到了发光的CdTe壳。多功能微球在水中和粗糙表面具有优异的溶解性，为固定甲胎蛋白（AFP）抗体（Ab_2）提供Fe-3O_4 @ MnCO_3 @ PE-CdTe-Ab_2结构提供了友好的微环境。通过使用Fe_3O_4 @ MnCO_3 @ PEs-CdTe-Ab_2生物共轭物作为标记，开发了一种有前途且用途广泛的平台，用于癌症生物标记物AFP的荧光成像和电化学免疫传感。制备的电化学免疫传感器具有很高的灵敏度和选择性，检测限为0.3 pg mL〜（-1）。

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