Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties

Wang J.; Sintim H.O.

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Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties

机译：二烷基氨基-2,4-二羟基苯甲酸，易合成的新霉素和新霉素，具有可比的抗菌性能

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Function matters more than synthesis: Simple analogues of platensimycin, nanomolar inhibitors of bacterial FabF enzymes, are made in just two-flask reactions from commercially available aldehydes. These readily synthesized analogues are as effective as platensimycin in killing several bacterial strains.

机译：功能比合成更重要：细菌FabF酶的纳摩尔抑制剂Platensimycin的简单类似物仅通过两瓶反应由市售的醛制成。这些易于合成的类似物在杀死几种细菌菌株方面与板霉素一样有效。

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《Chemistry: A European journal》 |2011年第12期|共6页
作者
Wang J.; Sintim H.O.;
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正文语种 eng
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关键词
antibiotics; fatty acid synthase; natural products; platencin; platensimycin;

机译：抗生素;脂肪酸合酶;天然产物;板霉素;板霉素;

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1. Dialkylamino-2,4-dihydroxybenzoic Acids as Easily Synthesized Analogues of Platensimycin and Platencin with Comparable Antibacterial Properties [J] . Jingxin Wang Prof. Dr. Herman O. Sintim Chemistry - A European Journal . 2011,第12期

机译：二烷基氨基-2,4-二羟基苯甲酸可轻松合成具有可比抗菌素的Platensimycin和Platencin类似物
2. Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029 [J] . Dong Liao-Bin, Rudolf Jeffrey D., Shen Ben Bioorganic and medicinal chemistry . 2016,第24期

机译：链霉菌SB12029的抗菌含硫平台霉素和平台蛋白同源物
3. Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant i>Staphylococcus aureus/i> [J] . Lin Qiu, Kai Tian, Zhongqing Wen, Journal of natural products . 2018,第2期

机译：生物菊体立体选择性苏氏霉菌加入导致抗甲氧脲抗甲氧化菌素的铂霉素和Platencin硫类似物。金黄色葡萄球菌
4. SINGLE AMINO ACID SUBSTITUTION ANALOGUES OF THE ANTIBACTERIAL PEPTIDE A7-ANOPLIN [C] . Paul R. Hansen, Dan Ifrah, Henriette T. Lianee the European Peptide Symposium . 2007

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5. Synthesis and properties of modified nucleic acids and analogues. [D] . Wojciechowski, Filip. 2009

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6. A Mutasynthetic Library of Platensimycin and Platencin Analogues [O] . Liao-Bin Dong, Jeffrey D. Rudolf, Ben Shen -1

机译：板蛋白和板蛋白类似物的突变合成文库
7. Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus [O] . Lin Qiu, Kai Tian, Zhongqing Wen, 2018

机译：生物摩托的立体选择性Sulfa-Michael添加导致抗甲氧西林金黄色葡萄球菌的铂霉素和Platencin硫类似物

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties

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