Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for ~(64)Cu radiopharmaceuticals

Liu S.; Li Z.; Yap L.-P.; Huang C.-W.; Park R.; Conti P.S.

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Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for ~(64)Cu radiopharmaceuticals

机译：〜（64）Cu放射性药物的新型多价双功能螯合剂的高效制备和生物学评价

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摘要

A novel bifunctional chelator: The sarcophagine motif was used in the development of a novel bifunctional chelator for ~(64)Cu radiopharmaceuticals (see figure). The high tumor-targeting efficiency and great stability of the ~(64)Cu-BaBaSar-RGD_2 conjugate were validated in a U87MG glioma xenograft mouse model.

机译：一种新型的双功能螯合剂：在开发〜（64）Cu放射性药物的新型双功能螯合剂中使用了石棺基序（见图）。在U87MG胶质瘤异种移植小鼠模型中验证了〜（64）Cu-BaBaSar-RGD_2偶联物的高肿瘤靶向效率和高稳定性。

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《Chemistry: A European journal》 |2011年第37期|共4页
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Liu S.; Li Z.; Yap L.-P.; Huang C.-W.; Park R.; Conti P.S.;
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正文语种 eng
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bifunctional chelators; copper-64; integrin αvβ 3; radiopharmaceuticals; RGD; sarcophagine;

机译：双功能螯合剂;铜64;整合素αvβ3;放射性药物;RGD;石棺;

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1. Efficient Preparation and Biological Evaluation of a Novel Multivalency Bifunctional Chelator for 64Cu Radiopharmaceuticals [J] . Shuanglong Liu, Zibo Li, Li-Peng Yap Chiun-Wei Huang Ryan Park Prof. Peter S. Conti Chemistry - A European Journal . 2011,第37期

机译：新型 64 Cu放射性药物多价双功能螯合剂的高效制备和生物学评价
2. An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo(6.6.6)icosane-1-ylamino)methyl)benzoic acid, for 64Cu radiopharmaceuticals. [J] . Cai H, Li Z, Huang CW, Nuclear Medicine and Biology . 2010,第1期

机译：新型笼状双功能螯合剂4-（（8-氨基-3,6,10,13,16,19-六氮杂双环（6.6.6）二十烷-1-基氨基）甲基）苯甲酸的改进的合成和生物学评价酸，用于64Cu放射性药物。
3. Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development [J] . De Silva Ravindra A., Jain Sandeep, Lears Kimberly A., Nuclear Medicine and Biology . 2012,第8期

机译：铜64放射性标记和双功能螯合剂用于放射性药物开发的生物学评估
4. ~(44m)Sc/~(44)Sc in Vivo Generator: First Experience of Vector Radiolabeling and Biological Evaluation for Radiopharmaceutical Development [C] . S. Huclier-Markai, C. Alliot, J. Rousseau, 8th International Conference on Isotopes 2014 . 2014

机译：体内发生器中的〜（44m）Sc /〜（44）Sc：载体放射性标记和放射性药物开发生物学评估的初步经验
5. Preparation and evaluation of potential radiopharmaceuticals labeled with gallium-67,68, indium-111 and copper-64,67, relationships between structure and biological activity. [D] . Jones-Wilson, Teresa Michelle. 1995

机译：镓67,68，铟111和铜64,67标记的潜在放射性药物的制备和评估，结构与生物活性之间的关系。
6. Efficient Preparation and Biological Evaluation of a Novel Multivalency Bifunctional Chelator for 64Cu Radiopharmaceuticals [O] . Shuanglong Liu, Zibo Li, Li-Peng Yap, -1

机译：64CU放射性药物新型多价双官能螯合剂的高效制备及生物学评价
7. Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development [O] . Ravindra A. De Silva, Sandeep Jain, Kimberly A. Lears, 2012

机译：铜-64放射性螯合剂的放射性螯合剂，用于放射性药物发育的双官能螯合剂

Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for ~(64)Cu radiopharmaceuticals

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