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首页> 外文期刊>Chemistry: A European journal >Anti-hepatitis b virus active lactones from the traditional chinese herb: Swertia mileensis
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Anti-hepatitis b virus active lactones from the traditional chinese herb: Swertia mileensis

机译：来自传统中草药的抗乙型肝炎病毒活性内酯：Swertia mileensis

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摘要

Swerilactones H-K (1-4), which are four novel lactones with an unprecedented C29 skeleton, were isolated from Swertia mileensis (Qing-Ye-Dan), an endemic Chinese herb used for treating viral hepatitis. Their structures were determined by extensive spectroscopic and X-ray crystallographic diffraction analyses. Swerilactones H-K exhibit potent anti-hepatitis B virus activity against HBV DNA replication with IC_(50) values ranging from 1.53 to 5.34 M. For the first time, a plausible biogenetic pathway for swerilactones H-K, together with the previously reported swerilactones A-D is proposed. From a biogenetic point of view, swerilactones A-D are ascribed as secoiridoid dimers, and swerilactones H-K as secoiridoid trimers.
机译：Swerlactones H-K（1-4）是四个具有前所未有的C29骨架的新型内酯，从用于治疗病毒性肝炎的地方性中草药Swertia mileensis（Qing-Ye-Dan）中分离得到。它们的结构通过广泛的光谱和X射线晶体衍射分析来确定。 Swerlactones H-K对HBV DNA复制表现出有效的抗乙型肝炎病毒活性，IC_（50）值范围为1.53至5.34M。这是第一次，Swerlaclactones H-K与先前报道的swerilactones A-D一起提出了一条合理的生物遗传途径。从生物遗传学的观点来看，Swerlactones A-D被归类为类secrididoid二聚体，而Swerlactones H-K被归类为secidridoidoid三聚体。

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