Synthesis of 11-cis-retinoids by hydrosilylation-protodesilylation of an 11,12-didehydro precursor: Easy access to 11- and 12-mono- and 11,12-dideuteroretinoids

Bergueiro J.; Montenegro J.; Saá C.; López S.

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Synthesis of 11-cis-retinoids by hydrosilylation-protodesilylation of an 11,12-didehydro precursor: Easy access to 11- and 12-mono- and 11,12-dideuteroretinoids

机译：通过11,12-二氢氢化物的氢化硅烷化-去甲硅烷基化反应合成11-顺-维甲酸：容易获得11-和12-单-和11,12-二氢类维甲酸

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An expeditious, highly efficient approach to 11-cis-retinoids was achieved by semihydrogenation of a readily available 11-yne precursor through a hydrosilylation-protodesilylation protocol. The complete chemo-, regio-, and syn-stereoselectivity of the method also allowed direct access to 11- and 12-monodeutero-, and 11,12-dideutero-11-cis-retinoids. The analogous trans series was not accessible by this route, and was synthesized by means of Hiyama coupling.

机译：一种快速，高效的11-顺-类视黄醇方法是通过氢化硅烷化-原去甲硅烷基化方案对易于获得的11-炔前体进行半氢化而实现的。该方法具有完全的化学，区域和顺式立体选择性，还可以直接进入11-和12-单十二烷基和11,12-二十二烷基-十一-类视黄醇。通过该途径无法获得类似的反式序列，并且是通过Hiyama耦合合成的。

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《Chemistry: A European journal》 |2012年第44期|共8页
作者
Bergueiro J.; Montenegro J.; Saá C.; López S.;
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正文语种 eng
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cross-coupling; hydrosilylation; regioselectivity; retinoids; semihydrogenation;

机译：交叉偶联;氢化硅烷化;区域选择性;类维生素A;半氢化;

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1. Synthesis of 11-cis-retinoids by hydrosilylation-protodesilylation of an 11,12-didehydro precursor: Easy access to 11- and 12-mono- and 11,12-dideuteroretinoids [J] . Bergueiro J., Montenegro J., Saá C., Chemistry: A European journal . 2012,第44期

机译：通过11,12-二氢氢化物的氢化硅烷化-去甲硅烷基化反应合成11-顺-维甲酸：容易获得11-和12-单-和11,12-二氢类维甲酸
2. Stueies on the stereo- and enantioselective synthesis of 11,12-epoxysarcophytol-a,11,12-epoxysarcophytol-a acetate and 11,12-epoxycembrene-c.-synthesi [J] . 中国化学快报（英文版） . 1995,第003期

机译：关于11,12-环氧肌醇-a，11,12-环氧肌醇-乙酸酯和11,12-环氧脑-c.-synthesi的立体和对映选择性合成的研究
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机译：通过X射线晶体结构和NMR分析研究（±）-11,12-二氢十一-脱氧鹰嘴碱和（+）-11,13-二氢十一-脱氧鸟嘌呤碱，六氢苯并[c]菲啶类生物碱的构象研究
4. Sign Search and Sign Synthesis Made Easy to End User: The Paradigm of Building a SL Oriented Interface for Accessing and Managing Educational Content [C] . Eleni Efthimiou, Stavroula-Evita Fotinea, Panos Kakoulidis, International conference on universal access in human-computer interaction;International conference on human-computer interaction . 2017

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6. Synthesis of 11,12-Epoxydrim-8,12-en-11-ol, 11,12-Diacetoxydrimane, and Warburganal from (-)-Sclareol [O] . A. F. Barrero, M. Cortés, E. A. Manzaneda, 1999

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7. 5,6:11,12-Bis(ditelluro) Tetracene: Synthesis, Molecular and Supramolecular Properties [R] . Sandman, D. J., Stark, J. C., Foxman, B. M. 1982

机译：5,6：11,12-双（二硝基）噻吩：合成，分子和超分子性质

Synthesis of 11-cis-retinoids by hydrosilylation-protodesilylation of an 11,12-didehydro precursor: Easy access to 11- and 12-mono- and 11,12-dideuteroretinoids

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