New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies

Li M.-J.; Wong K.M.-C.; Yi C.; Yam V.W.-W.

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New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies

机译：香豆素衍生物官能化的新型钌（II）配合物：合成，基于能量转移的酯酶传感，细胞毒性和成像研究

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Two new bichromophoric ruthenium(II) complexes, [Ru(bpy) _2(bpy-CM)](PF _6) _2 and [Ru(bpy) _2(bpy-CM343)](PF _6) _2 (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated. Woodruff-not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The Ru ~II complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure).

机译：两个新的双色钌（II）络合物[Ru（bpy）_2（bpy-CM）] [PF _6）_2和[Ru（bpy）_2（bpy-CM343）] [PF _6）_2（bpy = 2,2已经设计并合成了带有附加的香豆素配体的β-联吡啶，CM ＝香豆素。通过使用UV / Vis和发光光谱法研究了配合物基于能量转移的酯酶传感。还研究了一种复合物的细胞毒性和细胞摄取。伍德拉夫-不仅美味！已经合成了两个新的带有发香豆素配体的双色钌（II）配合物。通过使用紫外/可见和发光光谱研究了配合物基于能量转移的酯酶传感。发现含有香豆素343衍生物的Ru〜II复合物对HepG2细胞仅表现出轻微的细胞毒性，并且很容易被活细胞吸收以显示对酯酶的明显反应（见图）。

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《Chemistry: A European journal》 |2012年第28期|共7页
作者
Li M.-J.; Wong K.M.-C.; Yi C.; Yam V.W.-W.;
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正文语种 eng
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coumarins; energy transfer; luminescence; ruthenium;

机译：香豆素;能量转移;发光;钌;

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1. New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies [J] . Li M.-J., Wong K.M.-C., Yi C., Chemistry: A European journal . 2012,第28期

机译：香豆素衍生物官能化的新型钌（II）配合物：合成，基于能量转移的酯酶传感，细胞毒性和成像研究
2. Synthesis, characterization, cytotoxic activities, and DNA-binding studies of ternary copper(II) complexes with new coumarin derivatives [J] . Jia L., Xu X.-M., Xu J., Chemical and Pharmaceutical Bulletin . 2010,第8期

机译：具有新香豆素衍生物的三元铜（II）配合物的合成，表征，细胞毒活性和DNA结合研究
3. Synthesis, Characterization, Cytotoxic Activities, and DNA-Binding Studies of Ternary Copper(II) Complexes with New Coumarin Derivatives [J] . Chemical and Pharmaceutical Bulletin . 2010,第8期

机译：新型香豆素衍生物三元铜（II）配合物的合成，表征，细胞毒活性和DNA结合研究
4. New complexes of lanthanum La(III) and Cerium Ce(III) with bis-coumarins. Synthesis, characterization and cytotoxicity for human lymphoblastoid cells (MT-2) [C] . Kostova, I., Raleva, Workshop on Macro, Trace and Ultratrace Elements; 20040924-25; Jena(DE) . 2004

机译：镧La（III）和Ce Ce（III）与双香豆素的新配合物。人淋巴母细胞（MT-2）的合成，表征和细胞毒性
5. Photochemistry of group 8 metal complexes of type [M(bpy)2 cyanogen] (M = iron, ruthenium). Photosynthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) compounds, or, Photoassisted synthesis of heteroleptic iron(II) compounds and photoionization of ruthenium(II) complexes. [D] . Turner, David Benjamin. 2009

机译：[M（bpy）2氰基]类型的第8组金属配合物的光化学（M =铁，钌）。杂合铁（II）化合物的光合作用和钌（II）化合物的光电离，或者杂合铁（II）化合物的光辅助合成和钌（II）配合物的光电离。
6. Synthesis Characterization and Cytotoxic Activity of NewLanthanum(III) Complexes of Bis-Coumarins [O] . Irena Kostova, Georgi Momekov, Tzvetomira Tzanova, 2006

机译：新型的合成表征和细胞毒活性双香豆素镧（III）配合物
7. Synthesis, Cytotoxic Effect, and Structure-Activity Relationship of Pd(II) Complexes with Coumarin Derivatives [O] . -1

机译：Pd（II）与香豆素衍生物的合成，细胞毒性效应和结构 - 活性关系
8. Effects of Solvation on One- and Two-Photon Spectra of Coumarin Derivatives: A Time-Dependent Density Functional Theory Study (Postprint). [R] . Pachter, R., Nguyen, K. A., Day, P. N. 2007

机译：溶剂化对香豆素衍生物的单光子和双光子光谱的影响：时间依赖的密度泛函理论研究（后印刷）。

New ruthenium(II) complexes functionalized with coumarin derivatives: Synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies

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