A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1

Battilocchio C.; Deadman B.J.; Nikbin N.; Kitching M.O.; Baxendale I.R.; Ley S.V.

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A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1

机译：SR48692的机器辅助流动合成：用于研究神经降压素受体1的探针

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Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.

机译：在这里，我们报告直接比较传统的批处理模式合成的Meclinertant（SR48692，1），一种神经降压素受体1拮抗剂，与它的机器辅助流动化学替代品相似。通过使用这些辅助工具，与固体支持的试剂和清除剂结合，可以观察到许多工艺优势。但是，必须注意不要将这些技术转换为不存在的问题的昂贵解决方案。

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《Chemistry: A European journal》 |2013年第24期|共14页
作者
Battilocchio C.; Deadman B.J.; Nikbin N.; Kitching M.O.; Baxendale I.R.; Ley S.V.;
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正文语种 eng
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batch processes; flow chemistry; medicinal chemistry; organic chemistry; synthetic methods;

机译：批处理;流化学;药物化学;有机化学;合成方法;

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1. A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1 [J] . Battilocchio C., Deadman B.J., Nikbin N., Chemistry: A European journal . 2013,第24期

机译：SR48692的机器辅助流动合成：用于研究神经降压素受体1的探针
2. EFFECT OF THE NEUROTENSIN RECEPTOR ANTAGONIST SR48692 ON RAT BLOOD PRESSURE MODULATION BY NEUROTENSIN [J] . Gully D., Canton M., Rostene W., Life sciences . 1996,第8期

机译：神经紧张素受体拮抗剂SR48692对神经紧张素对大鼠血压的调节作用
3. Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer [J] . Liu Jin, Agopiantz Mikael, Poupon Joel, Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第21期

机译：通过增强卵巢癌中的凋亡和抑制药物流出，神经调节素受体1对拮抗剂SR48692改善对卡铂的反应
4. Synthesis of metabolically stable ~(99m)Tc-labeled neurotensin(8-13)analogs for tumour diagnosis [C] . Veronique Maes, Dirk Tourwe, Peter Blauenstein International Peptide Symposium;European Peptide Symposium . 2005

机译：代谢稳定〜（99M）的肿瘤诊断的代谢稳定〜（99m）的核标记的神经囊素（8-13）类类似物
5. Identification of novel pharmacological approaches to inhibit neurotensin receptor-1 mitogenic signaling in breast cancer cells. [D] . Heakal, Yasser. 2009

机译：鉴定抑制乳腺癌细胞中神经降压素受体1有丝分裂信号的新型药理学方法。
6. Characterization of the effect of SR48692 on inositol monophosphate cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. [O] . F. Oury-Donat, O. Thurneyssen, N. Gonalons, 1995

机译：SR48692对与神经元和非神经元细胞中神经降压素受体激活有关的肌醇单磷酸酯环状GMP和环状AMP反应的影响的表征。
7. Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer [O] . Jin Liu, Mikaël Agopiantz, Joël Poupon, 2017

机译：通过增强卵巢癌中的凋亡和抑制药物流出，神经调节素受体1对拮抗剂SR48692改善对卡铂的反应
8. Mechanisms of Radiosensitization by the Neurotensin Receptor Antagonist SR48692 in Prostate Cancer Models. [R] . Dziegielewski, J. 2011

机译：神经降压素受体拮抗剂sR48692对前列腺癌模型的放射敏感性机制。

A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1

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