• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Spindle-Like Polypyrrole Hollow Nanocapsules as Multifunctional Platforms for Highly Effective Chemo–Photothermal Combination Therapy of Cancer Cells in Vivo
【24h】

Spindle-Like Polypyrrole Hollow Nanocapsules as Multifunctional Platforms for Highly Effective Chemo–Photothermal Combination Therapy of Cancer Cells in Vivo

机译：纺锤状聚吡咯空心纳米胶囊作为体内癌细胞癌细胞高效化学-光热联合治疗的多功能平台

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The monodispersed spindle-like polypyrrole hollow nanocapsules (PPy HNCs) as the multifunctional platforms for combining chemotherapy with photothermal therapy for cancer cells are reported. Whereas the hollow cavity of nanocapsules can be used to load the anticancer drug (i.e., doxorubicin) for chemotherapy, the PPy shells can convert NIR light into heat for photothermal therapy. The release of the drug from the spindle-like PPy HNCs is pH-sensitive and near-infrared (NIR) light-enhanced. More importantly, the spindle-like PPy HNCs can penetrate cells more rapidly and efficiently in comparison with the spherical PPy HNCs. Both in vitro and in vivo experiments demonstrated that the combination of DOX-loaded spindle-like PPy HNCs and NIR light provide a highly effective and feasible chemo-photothermal therapy cancer method with a synergistic effect. Owing to their high photothermal conversion efficiency, large hollow cavity, and good biocompatibility, the spindlelike PPy HNCs could be used as a promising new cancer drug-nanocarrier and photothermal agent for localized tumorous chemo-photothermal therapy.
机译：据报道，单分散纺锤状的聚吡咯空心纳米胶囊（PPy HNCs）是将化疗与光热疗法相结合的多功能平台。纳米胶囊的空心腔可用于加载抗癌药物（即阿霉素）进行化学疗法，而PPy壳可将近红外光转换为热能进行光热疗法。纺锤状PPy HNC释放的药物对pH敏感，并且近红外（NIR）光增强。更重要的是，与球形PPy HNC相比，纺锤形的PPy HNC可以更快，更有效地穿透细胞。体外和体内实验均表明，装载DOX的纺锤状PPy HNC和NIR光的组合提供了一种高效且可行的化学光热疗法癌症方法，具有协同效应。由于主轴状的PPy HNC具有很高的光热转化效率，大的空腔和良好的生物相容性，因此可以作为一种有前景的新型癌症药物-纳米载体和光热剂用于局部肿瘤化学光热疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号