• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Silica Nanowire Arrays for Diffraction-Based Bioaffinity Sensing
【24h】

Silica Nanowire Arrays for Diffraction-Based Bioaffinity Sensing

机译：用于基于衍射的生物亲和力传感的二氧化硅纳米线阵列。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Arrays of electrodeposited silica nanowires (SiO_2 NWs) have been fabricated over large areas (cm2) on fluoropolymer thin films attached to glass substrates by a combination of photolithography and electrochemically triggered sol-gel nanoscale deposition. Optical and scanning electron microscopy (SEM) measurements revealed that the SiO_2 NW arrays had an average spacing of ten micrometers and an average width of 700 nm with a significant grain structure that was a result of the sol-gel deposition process. The optical diffraction properties at 633 nm of the SiO_2 NW arrays were characterized when placed in contact with solutions by using a prism-coupled total internal reflection geometry; quantification of changes in these diffraction properties was applied in various sensing applications. Bulk refractive index sensing by using the SiO_2 NW grating was demonstrated with a sensitivity of 1.30×10~(-5) RIU. Toposelectively chemically modified SiO_2 NW arrays were used for diffraction biosensing measurements of surface binding events, such as the electrostatic adsorption of gold nanoparticles and the bioaffinity adsorption of streptavidin onto a biotin monolayer. Finally, the application of the SiO_2 NW arrays for practical medical-diagnostic applications was demonstrated by monitoring the diffraction of SiO_2 NW arrays functionalized with a single-stranded (ss)DNA aptamer to detect human α-thrombin from solutions at sub-pathologic nanomolar concentrations.
机译：通过光刻和电化学触发的溶胶-凝胶纳米级沉积相结合的方法，已在附着于玻璃基板的含氟聚合物薄膜上大面积（cm2）上制造了电沉积二氧化硅纳米线（SiO_2 NWs）阵列。光学和扫描电子显微镜（SEM）测量表明，SiO_2 NW阵列的平均间距为10微米，平均宽度为700 nm，具有明显的晶粒结构，这是溶胶-凝胶沉积过程的结果。当通过与棱镜耦合的全内反射几何结构与溶液接触时，表征了SiO_2 NW阵列在633 nm处的光学衍射特性。这些衍射特性变化的量化被应用于各种传感应用中。利用SiO_2NW光栅对体折射率进行了检测，其灵敏度为1.30×10〜（-5）RIU。拓扑选择性化学修饰的SiO_2 NW阵列用于表面结合事件的衍射生物传感测量，例如金纳米颗粒的静电吸附和链霉亲和素在生物素单层上的生物亲和力吸附。最后，通过监测用单链（ss）DNA适体功能化的SiO_2 NW阵列的衍射，从亚病理学纳摩尔浓度的溶液中检测人α-凝血酶，证明了SiO_2 NW阵列在实际医学诊断中的应用。 。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号