Intermolecular Peptide Cross-Linking by Using Diaminodicarboxylic Acids

Kamalov Meder; Kaur Harveen; Brimble Margaret A.

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Intermolecular Peptide Cross-Linking by Using Diaminodicarboxylic Acids

机译：使用二氨基二羧酸的分子间肽交联

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Synthetic methods aimed at preparing peptides cross-linked by diaminodiacids remain an important chemical challenge. These cross-links are known to play a crucial role on the activity, structural stability, and folding of the host peptides and proteins. Recent developments in the syntheses of such systems have led to intriguing advances in the understanding of intermolecular side-chain cross-linking and the role that these structural motifs play in the biochemistry of proteins. Herein we provide an overview of the existing synthetic methodology that has been developed to effect protein cross-linking using diaminodiacids.

机译：旨在制备被二氨基二酸交联的肽的合成方法仍然是重要的化学挑战。已知这些交联在宿主肽和蛋白质的活性，结构稳定性和折叠中起关键作用。这种系统的合成的最新发展已引起人们对分子间侧链交联以及这些结构基序在蛋白质的生物化学中的作用的理解方面的引人注目的进展。本文中，我们概述了已开发出来的使用二氨基二酸实现蛋白质交联的现有合成方法。

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《Chemistry: A European journal》 |2016年第11期|共10页
作者
Kamalov Meder; Kaur Harveen; Brimble Margaret A.;
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Alzheimer's disease; amino acids; biochemistry; peptide synthesis; proteins;

机译：阿尔茨海默氏病;氨基酸;生物化学;肽合成;蛋白质;

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1. Intermolecular Peptide Cross-Linking by Using Diaminodicarboxylic Acids [J] . Kamalov Meder, Kaur Harveen, Brimble Margaret A. Chemistry: A European journal . 2016,第11期

机译：使用二氨基二羧酸的分子间肽交联
2. Stereospecific Synthesis of Cyclic Hydrazoacetic Acids and meso-Diaminodicarboxylic Acids [J] . Yasushi Arakawa, Takahiro Goto, Kazuya Kawase, Chemical and Pharmaceutical Bulletin . 1998,第4期

机译：环状羟基乙酸和内消旋二氨基二羧酸的立体定向合成
3. Identification of cyanogen bromide peptides involved in intermolecular cross-linking of bovine type III collagen [J] . A C Nicholls, A J Bailey The biochemical journal . 1980,第1期

机译：鉴定与牛III型胶原分子间交联的溴化氰肽
4. UV-induced protein-RNA cross-linking: Identification of RNA-binding domains, peptides, and amino acids [C] . Katharina Kramer, Timo Sachsenberg, Oliver Kohlbacher, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：UV诱导的蛋白质RNA交联：鉴定RNA结合结构域，肽和氨基酸
5. NMR studies of intermolecular interactions of nucleic acids with polyamide ligands and a synthetic peptide. [D] . Chang, Cynthia Ching. 1999

机译：核磁共振研究核酸与聚酰胺配体和合成肽的分子间相互作用。
6. Chemical cross-linking with thiol-cleavable reagents combined with differential mass spectrometric peptide mapping--a novel approach to assess intermolecular protein contacts. [O] . K. L. Bennett, M. Kussmann, P. Björk, 2000

机译：化学与硫醇可裂解试剂的交联结合差分质谱肽图分析-一种评估分子间蛋白质接触的新方法。
7. Chemical cross-linking with thiol-cleavable reagents combined with differential mass spectrometric peptide mapping--a novel approach to assess intermolecular protein contacts. [O] . Bennett, K. L., Kussmann, M., Björk, P., 2000

机译：化学与硫醇可裂解试剂的交联结合差分质谱肽图分析-一种评估分子间蛋白质接触的新方法。
8. Pyrolysis of coal model compounds containing aromatic carboxylic acids: The role of carboxylic acids in cross-linking reactions in low-rank coal [R] . Eskay, T. P. , Britt, P. F. , Buchanan, A. C. 1997

机译：含有芳香羧酸的煤模型化合物的热解：羧酸在低级煤中的交联反应中的作用

Intermolecular Peptide Cross-Linking by Using Diaminodicarboxylic Acids

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