Orthogonal Synthesis of Xeno Nucleic Acids

Fiers Guillaume; Chouikhi Dalila; Oswald Laurence; Al Ouahabi Abdelaziz; Chan-Seng Delphine; Charles Laurence; Lutz Jean-Francois

首页> 外文期刊>Chemistry: A European journal >Orthogonal Synthesis of Xeno Nucleic Acids

【24h】

Orthogonal Synthesis of Xeno Nucleic Acids

机译：异种核酸的正交合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase orthogonal "AB + CD" iterative strategy. In this approach, AB and CD building blocks containing carboxylic acid (A), azide (B), alkyne (C), and primary amine (D) functions are assembled together by successive copper-catalyzed azide-alkyne cycloaddition (CuAAC) and acid-amine coupling steps. Different PTzNA genetic sequences were prepared using a library of eight building blocks (i.e., four AB and four CD building blocks).

机译：借助于固相正交“ AB + CD”迭代策略合成了序列定义的肽三唑核酸（PTzNA）。通过这种方法，通过连续的铜催化的叠氮化物-炔烃环加成（CuAAC）和酸将包含羧酸（A），叠氮化物（B），炔烃（C）和伯胺（D）的AB和CD结构单元组装在一起-胺偶联步骤。使用8个构件（即4个AB和4个CD构件）的文库制备了不同的PTzNA基因序列。

著录项

来源
《Chemistry: A European journal》 |2016年第50期|共4页
作者
Fiers Guillaume; Chouikhi Dalila; Oswald Laurence; Al Ouahabi Abdelaziz; Chan-Seng Delphine; Charles Laurence; Lutz Jean-Francois;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
iterative chemistry; nucleic acids; orthogonal synthesis; sequence-controlled polymers; solid-phase synthesis;

机译：迭代化学核酸正交合成顺序控制聚合物固相合成;

相似文献

外文文献
中文文献
专利

1. Orthogonal Synthesis of Xeno Nucleic Acids [J] . Fiers Guillaume, Chouikhi Dalila, Oswald Laurence, Chemistry: A European journal . 2016,第50期

机译：异种核酸的正交合成
2. Synthesis of Peptide Nucleic Acid FRET Probes via an Orthogonally Protected Building Block for Post-Synthetic Labeling of Peptide Nucleic Acids at the 5-Position of Uracil [J] . Bereket Y.Oquare, John-Stephen Taylor Bioconjugate Chemistry . 2008,第11期

机译：通过正交保护的构建基合成肽核酸FRET探针，以在尿嘧啶的5位位置进行肽核酸的后合成标记
3. Clickable Nucleic Acids: Sequence- Controlled Periodic Copolymer/ Oligomer Synthesis by Orthogonal Thiol-X Reactions [J] . Xi Weixian, Pattanayak Sankha, Wang Chen, Angewandte Chemie . 2015,第48期

机译：可点击的核酸：通过正交硫醇-X反应进行序列控制的周期性共聚物/低聚物的合成
4. Aqueous Phase Sonogashira Cross-Coupling Reaction in Synthesis of Bile Acid Conjugates of Purine and Pyrimidine Nucleosides and Nucleoside Triphosphates; Towards Bile Acid -Functionalized Nucleic Acids [C] . Satu Ikonen, Radek Pohl, Michal Hocek European Symposium on Organic Chemistry . 2009

机译：水相Sonogashira交叉偶联反应在嘌呤和嘧啶核苷的合成中合成，嘧啶核苷和核苷三磷酸盐;朝向胆汁酸 - 官能化核酸
5. Chemical studies on the synthesis of nucleic acids and nucleic acid analogues. [D] . Miller, Tod Jeffrey. 1997

机译：核酸和核酸类似物合成的化学研究。
6. Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid [O] . Qi Wang, Lei Chen, Yitao Long, 2013

机译：异种核酸分子信标检测核酸
7. Cover Picture: Clickable Nucleic Acids: Sequence-Controlled Periodic Copolymer/Oligomer Synthesis by Orthogonal Thiol-X Reactions (Angew. Chem. Int. Ed. 48/2015) [O] . Weixian Xi, Sankha Pattanayak, Chen Wang, 2015

机译：封面图片：可点击的核酸：通过正交硫醇-X反应（Angew.Chem.Int.248 / 2015）的序列控制的周期性共聚物/低聚物合成。
8. Prebiotic Synthesis of Ethylenediamine Monoacetic Acid, The Repeating Unit of Peptide Nucleic Acids [R] . Nelson, K. E. , Miller, S. L. 1992

机译：益生元合成乙二胺单乙酸，肽核酸的重复单位

Orthogonal Synthesis of Xeno Nucleic Acids

摘要

著录项

相似文献

相关主题

期刊订阅