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首页> 外文期刊>American Journal of Physiology >Integrative control of rectoanal reflex in guinea pigs through lumbar colonic nerves.
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Integrative control of rectoanal reflex in guinea pigs through lumbar colonic nerves.

机译：通过腰部结肠神经对豚鼠直肠反射的综合控制。

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摘要

The aim of the present study was to analyze the neuromodulation of rectoanal reflex activity by lumbar sympathetic nerves in guinea pigs. The mechanical activities of the rectum were recorded with a balloon connected to a pressure transducer, and those of the internal anal sphincter (IAS) were recorded with a custom-made strain gauge force transducer. Gradual and sustained rectal distension evoked the rectoanal reflex, causing cholinergic contractions of the rectum and synchronous nitrergic relaxations of the IAS. Section of the lumbar colonic nerves enhanced both rectal contractions and IAS relaxations. Section of the 13th thoracic cord abolished both rectal contractions and IAS relaxations, but section of the lumbar colonic nerves restored them. Lumbar sympathectomy and pithing sacral cords greatly diminished these rectal contractions and IAS relaxations, but the intrinsic reflex component remained. NG-nitro-L-arginine methyl ester enhanced the intrinsic reflex-mediated contraction of the rectum and abolished reflex-mediated relaxation of the IAS and converted into cholinergic contractions. The present results indicate that the extrinsic lumbar inhibitory outflow causes marked inhibition of the rectoanal reflex via the lumbar colonic nerves.
机译：本研究的目的是分析豚鼠腰部交感神经对直肠反射活动的神经调节。用连接压力传感器的气囊记录直肠的机械活动，用定制的应变仪力传感器记录肛门内括约肌（IAS）的机械活动。逐渐和持续的直肠扩张引起直肠反射，引起直肠胆碱能收缩和IAS同步硝化松弛。腰结肠神经节增强了直肠收缩和IAS松弛。第13胸椎段消除了直肠收缩和IAS松弛，但是腰部结肠神经段恢复了它们。腰椎交感神经切除术和p骨髓髓切除术大大减少了这些直肠收缩和IAS松弛，但固有的反射成分仍然存在。 NG-硝基-L-精氨酸甲酯增强了内在的反射介导的直肠收缩，并消除了IAS的反射介导的松弛，并转化为胆碱能收缩。目前的结果表明，外在的腰椎抑制性流出引起经由腰结肠神经对直肠反射的明显抑制。

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