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首页> 外文期刊>American Journal of Physiology >Heart failure alters the strength and mechanisms of arterial baroreflex pressor responses during dynamic exercise.
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Heart failure alters the strength and mechanisms of arterial baroreflex pressor responses during dynamic exercise.

机译：心力衰竭会改变动态运动过程中动脉压力反射压力的强度和机制。

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摘要

Arterial baroreflex function is well preserved during dynamic exercise in normal subjects. In subjects with heart failure (HF), arterial baroreflex ability to regulate blood pressure is impaired at rest. However, whether exercise modifies the strength and mechanisms of baroreflex responses in HF is unknown. Therefore, we investigated the relative roles of cardiac output and peripheral vasoconstriction in eliciting the pressor response to bilateral carotid occlusion (BCO) in conscious, chronically instrumented dogs at rest and during treadmill exercise ranging from mild to heavy workloads. Experiments were performed in the same animals before and after rapid ventricular pacing-induced HF. At rest, the pressor response to BCO was significantly attenuated in HF (33.3 +/- 1.2 vs. 18.7 +/- 2.7 mmHg), and this difference persisted during exercise in part due to lower cardiac output responses in HF. However, both before and after the induction of HF, the contribution of vasoconstriction in active skeletal muscle toward the pressor response became progressively greater as workload increased. We conclude that, although there is an impaired ability of the baroreflex to regulate arterial pressure at rest and during exercise in HF, vasoconstriction in active skeletal muscle becomes progressively more important in mediating the baroreflex pressor response as workload increases with a pattern similar to that observed in normal subjects.
机译：在正常受试者的动态锻炼过程中，动脉压力反射功能得到了很好的保留。在患有心力衰竭（HF）的受试者中，静息时调节血压的动脉压力反射能力受损。但是，运动是否会改变HF中压力反射反应的强度和机制尚不清楚。因此，我们研究了静息和长期使用器械的狗在休息和跑步运动（从轻度到繁重的工作量）中，心输出量和周围血管收缩在引起对双侧颈动脉闭塞（BCO）的升压反应中的相对作用。在快速起搏诱发的心衰之前和之后，在相同的动物中进行实验。休息时，HF对BCO的升压反应显着减弱（33.3 +/- 1.2与18.7 +/- 2.7 mmHg），运动期间这种差异持续存在，部分原因是HF的心输出量降低。然而，在诱发HF之前和之后，随着工作量的增加，活动性骨骼肌中血管收缩对加压反应的贡献逐渐增大。我们得出的结论是，尽管HF中休息和运动过程中压力反射调节肺动脉压力的能力受损，但随着工作负荷的增加，活动性骨骼肌的血管收缩在介导压力反射压力反应中的作用越来越重要，其模式与观察到的相似。在正常人中。

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