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首页> 外文期刊>American Journal of Physiology >Distribution of stress and strain along the porcine aorta and coronary arterial tree.
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Distribution of stress and strain along the porcine aorta and coronary arterial tree.

机译：沿猪主动脉和冠状动脉树的应力和应变分布。

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The existence of a homeostatic state of stresses and strains has been axiomatic in the cardiovascular system. The objective of this study was to determine the distribution of circumferential stress and strain along the aorta and throughout the coronary arterial tree to test this hypothesis. Silicone elastomer was perfused through the porcine aorta and coronary arterial tree to cast the arteries at physiological pressure. The loaded and zero-stress dimensions of the vessels were measured. The aorta (1.8 cm) and its secondary branches were considered down to 1.5 mm diameter. The left anterior descending artery (4.5 mm) and its branches down to 10 microm were also measured. The Cauchy mean circumferential stress and midwall stretch ratio were calculated. Our results show that the stretch ratio and Cauchy stress were lower in the thoracic than in the abdominal aorta and its secondary branches. The opening angle (theta) and midwall stretch ratio (lambda) showed a linear variation with order number (n) as follows: theta = 10.2n + 63.4 (R(2) = 0.989) and lambda = 4.47 x 10(-2)n + 1.1 (R(2) = 0.995). Finally, the stretch ratio and stress varied between 1.2 and 1.6 and between 10 and 150 kPa, respectively, along the aorta and left anterior descending arterial tree. The relative uniformity of strain (50% variation) from the proximal aorta to a 10-microm arteriole implies that the vascular system closely regulates the degree of deformation. This suggests a homeostasis of strain in the cardiovascular system, which has important implications for mechanotransduction and for vascular growth and remodeling.
机译：在心血管系统中，应力和应变的稳态状态的存在是公理的。这项研究的目的是确定沿主动脉和整个冠状动脉树的圆周应力和应变的分布，以检验这一假设。通过猪主动脉和冠状动脉树灌注有机硅弹性体，在生理压力下浇铸动脉。测量了容器的载荷和零应力尺寸。主动脉（1.8厘米）及其次级分支被认为小至1.5毫米直径。还测量了左前降支动脉（4.5毫米）及其分支至10微米。计算了柯西平均圆周应力和中壁拉伸比。我们的结果表明，胸部的拉伸比和柯西应力低于腹主动脉及其次要分支。开角（θ）和中壁拉伸比（λ）随阶数（n）呈线性变化，如下所示：theta = 10.2n + 63.4（R（2）= 0.989）和lambda = 4.47 x 10（-2） n + 1.1（R（2）= 0.995）。最后，沿主动脉和左前降支动脉的拉伸比和应力分别在1.2和1.6之间以及10和150 kPa之间变化。从近端主动脉到10微米小动脉的应变的相对均匀性（50％的变化）意味着血管系统紧密调节变形程度。这表明心血管系统中应变的稳态，这对于机械转导以及血管生长和重塑具有重要意义。

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