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首页> 外文期刊>American Journal of Physiology >Impact of combined NO and PG blockade on rapid vasodilation in a forearm mild-to-moderate exercise transition in humans.
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Impact of combined NO and PG blockade on rapid vasodilation in a forearm mild-to-moderate exercise transition in humans.

机译：NO和PG联合封锁对人类前臂轻度至中度运动过渡中快速血管舒张的影响。

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摘要

We tested the hypothesis that nitric oxide (NO) and prostaglandins (PGs) contribute to the rapid vasodilation that accompanies a transition from mild to moderate exercise. Nine healthy volunteers (2 women and 7 men) lay supine with forearm at heart level. Subjects were instrumented for continuous brachial artery infusion of saline (control condition) or combined infusion of N(G)-nitro-L-arginine methyl ester (L-NAME) and ketorolac (drug condition) to inhibit NO synthase and cyclooxygenase, respectively. A step increase from 5 min of steady-state mild (5.4 kg) rhythmic, dynamic forearm handgrip exercise (1 s of contraction followed by 2 s of relaxation) to moderate (10.9 kg) exercise for 30 s was performed. Steady-state forearm blood flow (FBF; Doppler ultrasound) and forearm vascular conductance (FVC) were attenuated in drug compared with saline (control) treatment: FBF = 196.8 +/- 30.8 vs. 281.4 +/- 34.3 ml/min and FVC = 179.3 +/- 29.4 vs. 277.8 +/- 34.8 ml.min(-1).100 mmHg(-1) (both P < 0.01). FBF and FVC increased from steady state after release of the initial contraction at the higher workload in saline and drug conditions: DeltaFBF = 72.4 +/- 8.7 and 52.9 +/- 7.8 ml/min, respectively, and DeltaFVC = 66.3 +/- 7.3 and 44.1 +/- 7.0 ml.min(-1).100 mmHg(-1), respectively (all P < 0.05). The percent DeltaFBF and DeltaFVC were not different during saline infusion or combined inhibition of NO and PGs: DeltaFBF = 27.2 +/- 3.1 and 28.1 +/- 3.8%, respectively (P = 0.78) and DeltaFVC = 25.7 +/- 3.2 and 26.0 +/- 4.0%, respectively (P = 0.94). The data suggest that NO and vasodilatory PGs are not obligatory for rapid vasodilation at the onset of a step increase from mild- to moderate-intensity forearm exercise. Additional vasodilatory mechanisms not dependent on NO and PG release contribute to the immediate and early increase in blood flow in an exercise-to-exercise transition.
机译：我们检验了一氧化氮（NO）和前列腺素（PGs）有助于从轻度运动向中度运动过渡的快速血管舒张的假设。 9名健康志愿者（2名女性和7名男性）仰卧，前臂在心脏水平。对受试者进行连续肱动脉输注盐水（对照条件）或N（G）-硝基-L-精氨酸甲酯（L-NAME）和酮咯酸的联合输注（药物条件），以分别抑制NO合酶和环氧合酶。从5分钟的稳态轻度（5.4 kg）有节奏的动态前臂握力运动（收缩1 s，然后放松2 s）增加到30 s的中等强度（10.9 kg）运动。与生理盐水（对照组）相比，药物的稳态前臂血流量（FBF;多普勒超声）和前臂血管传导（FVC）减弱：FBF = 196.8 +/- 30.8 vs. 281.4 +/- 34.3 ml / min和FVC = 179.3 +/- 29.4 vs. 277.8 +/- 34.8 ml.min（-1）.100 mmHg（-1）（均P <0.01）。在盐水和药物条件下以较高的工作量释放初始收缩后，FBF和FVC从稳态增加：分别为DeltaFBF = 72.4 +/- 8.7和52.9 +/- 7.8 ml / min，以及DeltaFVC = 66.3 +/- 7.3和44.1 +/- 7.0 ml.min（-1）.100 mmHg（-1）（所有P <0.05）。盐水注入或联合抑制NO和PG的过程中DeltaFBF和DeltaFVC的百分比没有差异：DeltaFBF分别为27.2 +/- 3.1和28.1 +/- 3.8％（P = 0.78）和DeltaFVC = 25.7 +/- 3.2和26.0分别为+/- 4.0％（P = 0.94）。数据表明从轻度到中度强度的前臂锻炼逐步增加时，NO和血管舒张性PG并不需要快速扩张血管。不依赖于NO和PG释放的其他血管舒张机制会导致从运动到运动的过渡过程中血流的立即和早期增加。

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