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首页> 外文期刊>American Journal of Physiology >Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.
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Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers.

机译：半胱胺诱导的十二指肠溃疡大鼠中生长素释放肽的分泌增强。

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摘要

Ghrelin, produced and secreted by the A-like cells of the stomach, stimulates growth hormone secretion, gastric motility, and food intake. Cysteamine inhibits the release of somatostatin and induces the formation of duodenal ulcers in rats. The present study was conducted to investigate the dynamics of ghrelin secretion in rats treated with cysteamine. Male Wistar rats (7 wk old) were administered three doses of cysteamine (400 mg/kg) orally; at 50 h after the first dose, duodenal ulcers were induced, and the plasma level of somatostatin and gastric density of somatostatin-immunoreactive cells were significantly reduced. The plasma total and active ghrelin levels were significantly higher in the cysteamine-treated rats than in the control rats, whereas the gastric ghrelin levels, number of gastric ghrelin-immunoreactive cells, and preproghrelin mRNA expression levels were significantly lower. Even at the time points of 2 and 10 h after the first dose of cysteamine, at which time no significant ulcer formation or antral neutrophil accumulation was yet noted, a significant increase in the plasma ghrelin level and decrease in the gastric ghrelin level were observed. Furthermore, although lansoprazole treatment attenuated the duodenal ulceration induced by cysteamine, the increase in the plasma level of ghrelin could still be demonstrated. Because an inverse correlation was found between the plasma ghrelin and somatostatin levels, the inhibition of somatostatin secretion may be associated with the increased ghrelin secretion. In conclusion, an increase in the plasma ghrelin level precedes the formation of duodenal ulcers in rats treated with cysteamine.
机译：Ghrelin由胃的A样细胞产生和分泌，可刺激生长激素分泌，胃动力和食物摄入。半胱胺可抑制生长抑素的释放并诱导大鼠十二指肠溃疡的形成。进行本研究以研究半胱胺治疗的大鼠中生长素释放肽分泌的动力学。雄性Wistar大鼠（7周大）口服三剂半胱胺（400 mg / kg）。首次给药后50小时，诱发十二指肠溃疡，血浆生长抑素水平和生长抑素免疫反应细胞的胃密度明显降低。在半胱胺治疗的大鼠中血浆总和生长素释放肽水平显着高于对照组，而胃部生长素释放肽水平，胃部生长素释放肽免疫反应性细胞的数量和前生长素释放肽mRNA表达水平则显着降低。即使在第一剂半胱胺注射后2小时和10小时，仍未观察到明显的溃疡形成或窦性中性粒细胞积聚，血浆生长素释放肽水平显着升高，而胃部生长素释放肽水平则下降。此外，尽管兰索拉唑治疗可减轻由半胱胺引起的十二指肠溃疡，但仍可证明ghrelin的血浆水平升高。因为在血浆生长激素释放肽和生长抑素水平之间发现了负相关，生长抑素分泌的抑制可能与生长素释放肽的分泌增加有关。总之，在用半胱胺治疗的大鼠中，血浆生长素释放肽水平的升高先于十二指肠溃疡的形成。

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