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首页> 外文期刊>American Journal of Physiology >Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements.
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Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements.

机译：在评估部分血流储备和冠状动脉血流储备的测量结果时，应描述导丝的血流阻塞效应。

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Hemodynamic analysis was conducted to determine uncertainty in clinical measurements of coronary flow reserve (CFR) and fractional flow reserve (FFR) over pathophysiological conditions in a patient group with coronary artery disease during angioplasty. The vasodilation-distal perfusion pressure (CFR-p(rh)) curve was obtained for 0.35- and 0.46-mm guide wires. Our hypothesis is that a guide wire spanning the lesions elevates the pressure gradient and reduces the flow during hyperemic measurements. Maximal CFR-p(rh) was uniquely determined by the intersection of measured CFR and calculated p(rh) of native and residual epicardial lesions in patients without microvascular disease, during angioplasty. Extrapolation of the linear curve gave a zero-coronary flow mean pressure (p(zf)) of approximately 20 mmHg and a corresponding p(rh) of 55 mmHg in the native lesions, which coincided with the level that causes ischemia in human hearts. On this linear curve, values of CFR and FFRmyo (pathophysiological condition) and CFRg and FFRmyog (in the presence of the guide wire) were obtained in native and residual lesions. A strong linear correlation was found between CFR and CFRg [CFR = CFRg x 0.689 + 1.271 (R2= 0.99) for 0.46 mm and CFR = CFRg x 0.757 + 1.004 (R2= 0.99) for 0.35 mm] and between FFRmyo and FFRmyog [FFRmyo = FFRmyog x 0.737 + 0.263 (R2= 0.99) for 0.46 mm and FFRmyo = FFRmyog x 0.790 + 0.210 (R2= 0.99) for 0.35 mm]. This study establishes a strong correlation between CFR and CFRg and between FFRmyo and FFRmyog, which could be used to obtain the true state of occlusion in the coronary artery during angioplasty.
机译：进行血流动力学分析以确定在冠状动脉疾病患者血管成形术期间冠状动脉血流储备（CFR）和分数血流储备（FFR）在病理生理条件下的临床测量不确定性。对于0.35和0.46 mm的导丝，获得了血管舒张-远侧灌注压力（CFR-p（rh））曲线。我们的假设是跨过病变的导丝会在充血测量期间提高压力梯度并减少流量。在血管成形术中，无微血管疾病的患者中，自然CFR和pEC的自然和残余心外膜病变的p（rh）的相交值可以唯一地确定最大CFR-p（rh）。线性曲线的外推显示天然病变中的零冠状动脉血流平均压力（p（zf））约为20 mmHg，相应的p（rh）为55 mmHg，与导致人心脏缺血的水平相吻合。在该线性曲线上，在天然和残留病变中获得了CFR和FFRmyo（病理生理状况）以及CFRg和FFRmyog（在有导丝的情况下）的值。在CFR和CFRg之间[0.46 mm的CFR = CFRg x 0.689 + 1.271（R2 = 0.99），在0.35 mm的CFR = CFRg x 0.757 + 1.004（R2 = 0.99）]之间以及FFRmyo和FFRmyog [FFRmyo]之间发现强线性相关＝对于0.46mm为FFRmyog×0.737 + 0.263（R2 ＝ 0.99），对于FFRmyo ＝为FFRmyog×0.790 + 0.210（R2 ＝ 0.99）对于0.35mm。这项研究建立了CFR和CFRg之间以及FFRmyo和FFRmyog之间的强相关性，可用于获得血管成形术期间冠状动脉的真正闭塞状态。

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