• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Maturation of rat proximal tubule chloride permeability.
【24h】

Maturation of rat proximal tubule chloride permeability.

机译：大鼠近端小管氯化物通透性成熟。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have previously shown that neonate rabbit tubules have a lower chloride permeability but comparable mannitol permeability compared with adult proximal tubules. The surprising finding of lower chloride permeability in neonate proximals compared with adults impacts net chloride transport in this segment, which reabsorbs 60% of the filtered chloride in adults. However, this maturational difference in chloride permeability may not be applicable to other species. The present in vitro microperfusion study directly examined the chloride and mannitol permeability using in vitro perfused rat proximal tubules during postnatal maturation. Whereas there was no maturational change in mannitol permeability, chloride permeability was 6.3 +/- 1.3 x 10(-5) cm/s in neonate rat proximal convoluted tubule and 16.1 +/- 2.3 x 10(-5) cm/s in adult rat proximal convoluted tubule (P < 0.01). There was also a maturational increase in chloride permeability in the rat proximal straight tubule (5.1 +/- 0.6 x 10(-5) cm/s vs. 9.3+/- 0.6 x 10(-5) cm/s, P < 0.01). There was no maturational change in bicarbonate-to-chloride permeabilities (P(HCO3)/P(Cl)) in the rat proximal straight tubules (PST) and proximal convoluted tubules (PCT) or in the sodium-to-chloride permeability (P(Na)/P(Cl)) in the proximal straight tubule; however, there was a significant maturational decrease in proximal convoluted tubule P(Na)/P(Cl) with postnatal development (1.31 +/- 0.12 in neonates vs. 0.75 +/- 0.06 in adults, P < 0.001). There was no difference in the transepithelial resistance measured by current injection and cable analysis in the PCT, but there was a maturational decrease in the PST (7.2 +/- 0.8 vs. 4.6 +/- 0.1 ohms x cm2, P < 0.05). These studies demonstrate there are maturational changes in the rat paracellular pathway that impact net NaCl transport during development.
机译：先前我们已经证明，与成人近端小管相比，新生兔小管的氯离子渗透率较低，但甘露醇的渗透率却相当。与成人相比，新生儿近端较低的氯化物渗透性的令人惊讶的发现影响了这一部分的净氯化物运输，这重新吸收了成人中60％的过滤氯。但是，这种氯化物渗透率的成熟差异可能不适用于其他物种。目前的体外微灌注研究在出生后成熟期间使用体外灌注的大鼠近端小管直接检查了氯化物和甘露醇的渗透性。甘露醇渗透率没有成熟变化，新生大鼠近曲小管的氯化物渗透率为6.3 +/- 1.3 x 10（-5）cm / s，成年大鼠的氯化物渗透率为16.1 +/- 2.3 x 10（-5）cm / s大鼠近曲小管（P <0.01）。大鼠近端直小管的氯离子渗透率也逐渐增加（5.1 +/- 0.6 x 10（-5）cm / s与9.3 +/- 0.6 x 10（-5）cm / s，P <0.01 ）。大鼠近端直小管（PST）和近曲弯小管（PCT）或碳酸钠对氯化物的渗透性（P）中的碳酸氢盐对氯化物的渗透性（P（HCO3）/ P（Cl））没有成熟的变化（Na）/ P（Cl））在近端直小管中;然而，随着出生后发育的发展，近曲小管P（Na）/ P（Cl）的成熟度显着降低（新生儿为1.31 +/- 0.12，成人为0.75 +/- 0.06，P <0.001）。在PCT中通过电流注入和电缆分析测得的跨上皮电阻没有差异，但PST逐渐降低（7.2 +/- 0.8对4.6 +/- 0.1 ohm x cm2，P <0.05）。这些研究表明，大鼠副细胞途径中的成熟变化会影响发育期间的净NaCl转运。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号