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首页> 外文期刊>American Journal of Physiology >Impact of age and hyperglycemia on the mechanical behavior of intact human coronary arteries: an ex vivo intravascular ultrasound study.
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Impact of age and hyperglycemia on the mechanical behavior of intact human coronary arteries: an ex vivo intravascular ultrasound study.

机译：年龄和高血糖对完整人冠状动脉机械行为的影响：一项体外血管内超声研究。

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Despite their advantages, percutaneous coronary interventional procedures are less effective in diabetic patients. Changes in the mechanical properties of vascular walls secondary to long-term hyperglycemia as well as other factors such as age may influence coronary distensibility. This investigation is aimed at deciphering the extent of these effects on distensibility of postmortem human coronary arteries in a controlled manner. Excised human left anterior descending (LAD) coronary arteries were obtained within 24 h postmortem. With the use of intravascular ultrasound, vascular deformation was analyzed at midregions of 51 moderate lesions. Intraluminal pressure was systematically altered using a computerized pressure pump system and monitored by a pressure-sensing guidewire. Distensibility, a normalized compliance term, was defined as the change in lumen area normalized by the initial reference area over a given pressure interval. With the use of multivariate analysis and repeated-measures ANOVA, coronary distensibility was independently influenced by hyperglycemia and age (P < 0.05) through the entire pressure range. Within physiological pressure range, distensibility was significantly reduced with age in nonhyperglycemic coronary specimens (10.55 +/- 4.41 vs. 6.99 +/- 2.45, x10(3) kPa(-1), P = 0.01), whereas the hyperglycemic vessels were stiff even in the younger group (7.90 +/- 5.82 vs. 7.20 +/- 3.36, x10(3) kPa(-1), P = 0.79). Similar results were observed with stiffness index and elastic modulus of the arteries. Hyperglycemia and age independently influenced the distensibility of moderately atherosclerotic LAD coronary arteries. The stiffening with age was overshadowed in the hyperglycemic group by as-yet-undetermined factors.
机译：尽管有这些优点，但在糖尿病患者中，经皮冠状动脉介入手术的效果较差。长期高血糖继发的血管壁机械特性的变化以及其他因素（例如年龄）可能会影响冠脉扩张性。这项研究旨在以可控的方式解读这些对死后人冠状动脉可扩张性的影响程度。死后24小时内获得切除的人左前降支（LAD）冠状动脉。使用血管内超声，分析了51个中度病变的中部区域的血管变形。管腔内压力使用计算机压力泵系统进行系统更改，并通过压力感应导丝进行监控。可膨胀性，一个标准化的顺应性术语，被定义为在给定的压力间隔内通过初始参考面积标准化的管腔面积的变化。通过多变量分析和重复测量方差分析，在整个压力范围内，冠状动脉扩张性受高血糖和年龄的影响（P <0.05）。在生理压力范围内，非高血糖冠状动脉标本的可扩张性随着年龄的增长而显着降低（10.55 +/- 4.41 vs. 6.99 +/- 2.45，x10（3）kPa（-1），P = 0.01），而高血糖血管则僵硬即使在较年轻的组中也是如此（7.90 +/- 5.82与7.20 +/- 3.36，x10（3）kPa（-1），P = 0.79）。动脉的刚度指数和弹性模量观察到相似的结果。高血糖和年龄独立影响中度动脉粥样硬化LAD冠状动脉的扩张性。在高血糖组中，年龄的增长被尚未确定的因素所掩盖。

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