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首页> 外文期刊>American Journal of Physiology >A neural set point for the long-term control of arterial pressure: beyond the arterial baroreceptor reflex.
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A neural set point for the long-term control of arterial pressure: beyond the arterial baroreceptor reflex.

机译：长期控制动脉压的神经设定点：超出动脉压力感受器反射。

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Arterial baroreceptor reflex control of renal sympathetic nerve activity (RSNA) has been proposed to play a role in long-term control of arterial pressure. The hypothesis that the "set point" of the acute RSNA baroreflex curve determines the long-term level of arterial pressure is presented and challenged. Contrary to the hypothesis, studies on the long-term effects of sinoaortic denervation (SAD) on arterial pressure and RSNA, as well as more recent studies of chronic baroreceptor "unloading" on arterial pressure, suggest that the basal levels of sympathetic nerve activity and arterial pressure are regulated independent of arterial baroreceptor input to the brainstem. Studies of the effect of SAD on the long-term salt sensitivity of arterial pressure are consistent with a short-term role, rather than a long-term role for the arterial baroreceptor reflex in regulation of arterial pressure during changes in dietary salt intake. Renal denervation studies suggest that renal nerves contribute to maintenance of the basal levels of arterial pressure. However, evidence that baroreflex control of the kidney plays a role in the maintenance of arterial pressure during changes in dietary salt intake is lacking. It is proposed that a "baroreflex-independent" sympathetic control system must exist for the long-term regulation of sympathetic nerve activity and arterial pressure. The concept of a central nervous system "set point" for long-term control of mean arterial pressure (CNS-MAP set point), and its involvement in the pathogenesis of hypertension, is discussed.
机译：已经提出肾交感神经活性（RSNA）的动脉压力感受器反射控制在动脉压的长期控制中起作用。提出并挑战了急性RSNA压力反射曲线的“设定点”决定长期动脉压水平的假设。与该假设相反，对窦房神经去神经支配术（SAD）对动脉压和RSNA的长期影响的研究以及对慢性压力感受器“卸载”对动脉压的最新研究表明，交感神经活动和动脉压的调节独立于输入脑干的压力感受器。 SAD对动脉压的长期盐敏感性的影响的研究与饮食中盐摄入量变化期间动脉压力感受器反射在调节动脉压中的短期作用而非长期作用相一致。肾神经支配研究表明，肾神经有助于维持动脉血压的基础水平。但是，缺乏在饮食盐摄入量变化期间肾脏的压力反射控制在维持动脉压中起作用的证据。为了长期调节交感神经的活动性和动脉压，建议必须有一个“与压力反射无关的”交感神经控制系统。讨论了用于长期控制平均动脉压的中枢神经系统“设定点”（CNS-MAP设定点）的概念及其与高血压发病机理的关系。

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