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首页> 外文期刊>American Journal of Physiology >Arginine vasopressin reduces intestinal oxygen supply and mucosal tissue oxygen tension.
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Arginine vasopressin reduces intestinal oxygen supply and mucosal tissue oxygen tension.

机译：精氨酸加压素减少肠内氧气供应和粘膜组织的氧气张力。

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We investigated intestinal oxygen supply and mucosal tissue PO2 during administration of increasing dosages of continuously infused arginine vasopressin (AVP) in an autoperfused, innervated jejunal segments in anesthetized pigs. Mucosal tissue PO2 was measured by employing two Clark-type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Microvascular blood flow was assessed by laser-Doppler velocimetry. Systemic hemodynamic variables, mesenteric venous and systemic acid-base and blood gas variables, and lactate measurements were recorded. Measurements were performed at baseline and at 20-min intervals during incremental AVP infusion (n = 8; 0.007, 0.014, 0.029, 0.057, 0.114, and 0.229 IU.kg(-1).h(-1), respectively) or infusion of saline (n=8). AVP infusion led to a significant (P < .05), dose-dependent decrease in cardiac index (from 121 +/- 31 to 77 +/- 27 ml.kg(-1).min(-1) at 0.229 IU.kg(-1).h(-1)) and systemic oxygen delivery (from 14 +/- 3 to 9 +/- 3 ml.kg(-1).min(-1) at 0.229 IU.kg(-1).h(-1)) concomitant with an increase in systemic oxygen extraction ratio (from 31 +/- 4 to 48 +/- 10%). AVP decreased microvascular blood flow (from 133 +/- 47 to 82 +/- 35 perfusion units at 0.114 IU.kg(-1).h(-1)), mucosal tissue PO2 (from 26 +/- 7 to 7 +/- 2 mmHg at 0.229 IU.kg(-1).h(-1)), and microvascular hemoglobin oxygen saturation (from 51 +/- 9 to 26 +/- 12% at 0.229 IU.kg(-1).h(-1)) without a significant increase in mesenteric venous lactate concentration (2.3 +/- 0.8 vs. 3.4 +/- 0.7 mmol/l). We conclude that continuously infused AVP decreases intestinal oxygen supply and mucosal tissue PO2 due to a reduction in microvascular blood flow and due to the special vascular supply in the jejunal mucosa in a dose-dependent manner in pigs.
机译：我们研究了在麻醉猪的自动灌注神经支配空肠段中不断增加剂量的精氨酸加压素（AVP）的连续输注过程中的肠道氧气供应和粘膜组织PO2。通过使用两个Clark型表面氧电极来测量粘膜组织PO2。通过组织反射分光光度法测定空肠微血管血红蛋白的氧饱和度。通过激光多普勒测速仪评估微血管血流量。记录全身血流动力学变量，肠系膜静脉和全身酸碱和血气变量以及乳酸测量值。在增量AVP输注（分别为n = 8; 0.007、0.014、0.029、0.057、0.114和0.229 IU.kg（-1）.h（-1））期间以基线和20分钟的间隔进行测量盐水（n = 8）。 AVP输注导致心脏指数显着（P <.05），剂量依赖性降低（在0.229 IU下从121 +/- 31降至77 +/- 27 ml.kg（-1）.min（-1）。 kg（-1）.h（-1））和全身氧气输送（从0.2 IU.kg（-1时从14 +/- 3到9 +/- 3 ml.kg（-1）.min（-1） ）.h（-1））伴随着全身吸氧率的增加（从31 +/- 4增至48 +/- 10％）。 AVP减少微血管血流量（在0.114 IU.kg（-1）.h（-1）时从133 +/- 47降到82 +/- 35灌注单位），粘膜组织PO2（从26 +/- 7到7 +在0.229 IU.kg（-1）.h（-1）时为2 mmHg，微血管血红蛋白氧饱和度为0.229 IU.kg（-1）时从51 +/- 9到26 +/- 12％。 h（-1）），而肠系膜静脉乳酸浓度没有明显增加（2.3 +/- 0.8对3.4 +/- 0.7 mmol / l）。我们得出的结论是，由于微血管血流量减少以及空肠黏膜中特殊的血管供应（以剂量依赖性方式），AVP持续输注会减少肠道氧气供应和黏膜组织PO2。

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