Ang-1: Tie-ing up endothelial adhesion?

R. H. Adamson; F. E. Curry

首页> 外文期刊>American Journal of Physiology >Ang-1: Tie-ing up endothelial adhesion?

【24h】

Ang-1: Tie-ing up endothelial adhesion?

机译：血管紧张素-1（Ang-1）：系结内皮粘附吗？

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Less than ten years has passed since the protein angiopoietin-1 (Ang-1) was identified as a ligand for Tie-2, a tyrosine kinase receptor found principally on vascular endothelial cells (8). Ang-1 and its receptor, in concert with VEGF and its associated receptors, are essential for vasculogenesis during embryonic development. Transgenic mice in which either Ang-1 or Tie-2 is disrupted fail to develop fully functional cardiovascular systems, and either knockout induces embryonic lethality (17, 18). Understanding the coordinated actions of VEGF and Ang-1 during blood vessel development and during angiogen-esis in the adult is hoped to lead to therapeutic regulation of angiogenesis in a variety of clinically relevant states including promotion of vessel growth in wound healing or inhibition of angiogenesis in solid tumors

机译：自从蛋白血管生成素1（Ang-1）被鉴定为Tie-2的配体以来，不到十年已经过去了，Tie-2是一种主要在血管内皮细胞上发现的酪氨酸激酶受体（8）。 Ang-1及其受体与VEGF及其相关受体协同作用，对于胚胎发育过程中的血管生成至关重要。 Ang-1或Tie-2均被破坏的转基因小鼠无法发育出功能齐全的心血管系统，而任何一种基因敲除均会诱发胚胎致死性（17、18）。希望了解成年人血管发育期间和血管生成过程中VEGF和Ang-1的协同作用，有望导致在各种临床相关状态下血管生成的治疗性调节，包括促进伤口愈合中的血管生长或抑制血管生成在实体瘤中

著录项

来源
《American Journal of Physiology》 |2006年第1期|共3页
作者
R. H. Adamson; F. E. Curry;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
Tie; receptor; angiogenesis; bevacizumab;

机译：领带;受体;血管生成;贝伐单抗;

相似文献

外文文献
中文文献
专利

1. Ang-1: Tie-ing up endothelial adhesion? [J] . R. H. Adamson, F. E. Curry American Journal of Physiology . 2006,第1期

机译：血管紧张素-1（Ang-1）：系结内皮粘附吗？
2. Beyond tie-ing up endothelial adhesion: new insights into the action of angiopoietin-1 in regulation of microvessel permeability. [J] . He P Cardiovascular Research . 2009,第1期

机译：除了捆绑内皮粘附以外：血管生成素1在调节微血管通透性中的作用的新见解。
3. Beyond tie-ing up endothelial adhesion: new insights into the action of angiopoietin-1 in regulation of microvessel permeability [J] . Pingnian He* Cardiovascular Research . 2009,第1期

机译：除了捆绑内皮粘附以外：血管生成素-1在微血管通透性调节中的作用的新见解
4. Study on Adhesion Force of Endothelial Progenitor Cells and Endothelial Cells onDifferent Adhesion Substrates [C] . G.X. Wang, C.J. Tang, L. Xiao, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：血管内皮祖细胞与内皮细胞粘附力的研究不同的粘合基材
5. The engraftment problem: TNFalpha increases adhesion and migration of endothelial progenitor cells to vascular endothelial cells. [D] . Prisco, Anthony R. 2014

机译：植入问题：TNFα增加了内皮祖细胞向血管内皮细胞的粘附和迁移。
6. Expression and cell distribution of the intercellular adhesion molecule vascular cell adhesion molecule endothelial leukocyte adhesion molecule and endothelial cell adhesion molecule (CD31) in reactive human lymph nodes and in Hodgkins disease. [O] . L. P. Ruco, D. Pomponi, R. Pigott, 1992

机译：细胞间粘附分子血管细胞粘附分子内皮白细胞粘附分子和内皮细胞粘附分子（CD31）在反应性人类淋巴结和霍奇金病中的表达和细胞分布。
7. Ang-1 gene affect the inflammation of endothelial progenitor cells through NF-Kappa B signaling pathway [O] . 刘一叶 2010

机译：Ang-1基因通过NF-κB信号通路影响内皮祖细胞的炎症

Ang-1: Tie-ing up endothelial adhesion?

摘要

著录项

相似文献

相关主题

期刊订阅