Src protein tyrosine kinase family and acute inflammatory responses.

Okutani D; Lodyga M; Han B; Liu M

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Src protein tyrosine kinase family and acute inflammatory responses.

机译：Src蛋白酪氨酸激酶家族和急性炎症反应。

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Acute inflammatory responses are one of the major underlying mechanisms for tissue damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung injury. By use of cellular and molecular approaches and transgenic animals, Src protein tyrosine kinase (PTK) family members have been identified to be essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells. Src PTKs also play a critical role in the regulation of vascular permeability and inflammatory responses in tissue cells. Importantly, animal studies have demonstrated that small chemical inhibitors for Src PTKs attenuate tissue injury and improve survival from a variety of pathological conditions related to acute inflammatory responses. Further investigation may lead to the clinical application of these inhibitors as drugs for ischemia-reperfusion injury (such as stroke and myocardial infarction), sepsis, acute lung injury, and multiple organ dysfunction syndrome.

机译：急性炎症反应是多种疾病（例如缺血再灌注损伤，败血症和急性肺损伤）的组织损伤的主要潜在机制之一。通过使用细胞和分子方法以及转基因动物，Src蛋白酪氨酸激酶（PTK）家族成员已被确定对于募集和激活单核细胞，巨噬细胞，嗜中性粒细胞和其他免疫细胞至关重要。 Src PTK在调节组织细胞中的血管渗透性和炎症反应中也起着关键作用。重要的是，动物研究表明，Src PTK的小型化学抑制剂可减轻组织损伤并提高与急性炎症反应相关的多种病理状况的存活率。进一步的研究可能导致这些抑制剂作为缺血再灌注损伤（如中风和心肌梗塞），败血症，急性肺损伤和多器官功能障碍综合征的药物的临床应用。

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《American Journal of Physiology》 |2006年第2期|共13页
作者
Okutani D; Lodyga M; Han B; Liu M;
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正文语种 eng
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关键词
Inflammation; src-Family Kinases; 炎症; src族激酶类;

机译：Inflammation;src-Family Kinases;炎症;src族激酶类;

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专利

1. Src protein tyrosine kinase family and acute inflammatory responses. [J] . Okutani D, Lodyga M, Han B, American Journal of Physiology . 2006,第2期

机译：Src蛋白酪氨酸激酶家族和急性炎症反应。
2. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. [J] . C M Pleiman, M R Clark, L K Gauen, Molecular and Cellular Biology . 1993,第9期

机译：Src家族蛋白酪氨酸激酶p55blk，p59fyn和p56lyn上与效应分子磷脂酶C-γ2，微管相关的蛋白激酶，GTPase激活蛋白和磷脂酰肌醇3激酶相互作用的位点图谱。
3. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. [J] . S Mahajan, J Fargnoli, A L Burkhardt, Molecular and Cellular Biology . 1995,第10期

机译：Src家族蛋白酪氨酸激酶可诱导Bruton酪氨酸激酶的自激活。
4. Development of peptidomimetic substrates and inhibitors that bind to the peptide binding pocket of the catalytic site of p60~(C-src) protein tyrosine kinase [C] . Jayesh R.Kamath, Ruiwu Liu, Amanda M.Enstrom, the International Peptide Symposium . 2001

机译：拟肽底物和抑制剂的研制与P60〜（C-SRC）蛋白酪氨酸激酶催化位点的肽结合口袋结合
5. Suppression of Protein-Tyrosine Kinase Activities of Src Family by A Cytoplasmic Protein-Tyrosine Kinase Csk [D] . 名田, 茂之 1994

机译：细胞质蛋白酪氨酸激酶Csk抑制Src家族的蛋白酪氨酸激酶活性。
6. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. [O] . C M Pleiman, M R Clark, L K Gauen, 1985

机译：Src家族蛋白酪氨酸激酶p55blk，p59fyn和p56lyn上与效应分子磷脂酶C-γ2，微管相关蛋白激酶，GTPase激活蛋白和磷脂酰肌醇3-激酶相互作用的位点图谱。
7. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. [O] . Pleiman, C M, Clark, M R, Gauen, L K, 1993

机译：Src家族蛋白酪氨酸激酶p55blk，p59fyn和p56lyn上与效应分子磷脂酶C-γ2，微管相关蛋白激酶，GTPase激活蛋白和磷脂酰肌醇3-激酶相互作用的位点图谱。

Src protein tyrosine kinase family and acute inflammatory responses.

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