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首页> 外文期刊>American Journal of Physiology >Central neuropeptide Y induces proximal stomach relaxation via Y1 receptors in the dorsal vagal complex of the rat.
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Central neuropeptide Y induces proximal stomach relaxation via Y1 receptors in the dorsal vagal complex of the rat.

机译：中枢神经肽Y通过大鼠背迷走神经复合体中的Y1受体诱导胃近端舒张。

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摘要

Effects of neuropeptide Y (NPY) on motility of the proximal stomach was examined in anesthetized rats. Intragastric pressure was measured using a balloon situated in the proximal part of the stomach. Administration of NPY into the fourth ventricle induced relaxation of the proximal stomach in a dose-dependent manner. Administration of an Y1 receptor (Y1R) agonist [Leu31, Pro34]NPY induced a larger relaxation than NPY. The administration of an Y2 receptor agonist (NPY 13-36) did not induce significant changes in motility. Microinjections of [Leu31, Pro34]NPY into the caudal part of the dorsal vagal complex (DVC) induced relaxation of the proximal stomach. In contrast, similar injections into the intermediate part of the DVC increased IGP of the proximal stomach. Administration of NPY into the fourth ventricle did not induce relaxation after bilateral injections of the Y1R antagonist (1229U91) into the caudal DVC. These results indicate that NPY induces relaxation in the proximal stomach via Y1Rs situated in the DVC. Because bilateral vagotomy below the diaphragm abolished the relaxation induced by the administration of NPY into the fourth ventricle, relaxation induced by NPY is probably mediated by vagal preganglionic neurons. Intravenous injection of atropine methyl nitrate reduced relaxation induced by administration of NPY. Therefore, relaxation induced by NPY is likely mediated by peripheral cholinergic neurons.
机译：在麻醉的大鼠中检查了神经肽Y（NPY）对胃近端运动的影响。使用位于胃近端的气球测量胃内压力。 NPY进入第四脑室以剂量依赖的方式引起近端胃的松弛。施用Y1受体（Y1R）激动剂[Leu31，Pro34] NPY比NPY诱导更大的松弛。 Y2受体激动剂（NPY 13-36）的使用不会引起运动性的显着变化。向背迷走神经复合体（DVC）的尾部显微注射[Leu31，Pro34] NPY可引起近端胃部松弛。相反，向DVC的中间部分进行类似注射会增加近端胃的IGP。在双侧向尾DVC注射Y1R拮抗剂（1229U91）后，向第四脑室施用NPY不会引起松弛。这些结果表明，NPY通过位于DVC中的Y1R诱导胃近端的松弛。由于隔膜下方的双侧迷走神经切断术消除了将NPY注入第四脑室所引起的松弛，因此NPY引起的松弛可能是由迷走神经节前神经元介导的。静脉注射阿托品硝酸甲酯减少了由于施用NPY引起的松弛。因此，由NPY诱导的放松可能是由外周胆碱能神经元介导的。

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