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首页> 外文期刊>American Journal of Physiology >Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements.
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Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements.

机译：基于纵向激素测量，雄激素与动脉僵硬度之间的关系。

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Circulating testosterone levels (T) decrease with age in men. Low T has been associated with coronary disease and with risk factors for atherosclerosis. This study examines the relationship in men between androgenic hormones and arterial stiffness, a major risk factor for cardiovascular events. T, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS) were measured longitudinally over 33 yr (follow-up 11.8 +/- 8.3 yr) in 901 men from the Baltimore Longitudinal Study of Aging, of whom 206 (68.1 +/- 13.7 yr) underwent carotid duplex ultrasonography. The 901 men were used to characterize age-associated hormone levels by means of mixed-effects models. Hormone values were estimated for the 206 men at the time of ultrasonography. Free T index (FTI) was calculated by dividing T by SHBG. The arterial stiffness index was calculated from peak systolic and end diastolic diameters of the common carotid artery and simultaneous brachial artery blood pressure. T, FTI, and DHEAS were correlated negatively with age, pulse pressure (PP), and stiffness index (each P < 0.01), whereas SHBG was correlated positively with age and stiffness index (P < 0.01). However, T was the only hormone that predicted the stiffness index after adjustment for age, PP, fasting plasma glucose, body mass index, and total cholesterol. T values 5-10 yr before the carotid study also predicted the stiffness index (P < 0.05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function.
机译：男性的循环睾丸激素水平（T）随年龄下降。低T与冠心病和动脉粥样硬化的危险因素有关。这项研究检查了雄激素与动脉硬化之间的关系，后者是心血管事件的主要危险因素。在巴尔的摩纵向老龄化研究的901名男性中，对33岁（随访11.8 +/- 8.3岁）中的T，性激素结合球蛋白（SHBG）和脱氢表雄酮硫酸盐（DHEAS）进行了纵向测量，其中206（68.1） +/- 13.7岁）接受了颈动脉双工超声检查。 901名男性通过混合效应模型来表征与年龄相关的激素水平。在超声检查时估计了206名男性的激素值。通过将T除以SHBG来计算游离T指数（FTI）。根据颈总动脉的收缩压峰值和舒张末期直径以及同时的肱动脉血压来计算动脉僵硬度指数。 T，FTI和DHEAS与年龄，脉压（PP）和刚度指数呈负相关（每个P <0.01），而SHBG与年龄和刚度指数呈正相关（P <0.01）。但是，T是唯一可以预测年龄，PP，空腹血糖，体重指数和总胆固醇的刚性指数的激素。颈动脉研究前5-10年的T值也预示了刚度指数（P <0.05）。因此，低T对男性心血管系统的不利影响可能部分通过T对血管结构和功能的影响来介导。

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