• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Long-range negative correlation of glucose dynamics in humans and its breakdown in diabetes mellitus.
【24h】

Long-range negative correlation of glucose dynamics in humans and its breakdown in diabetes mellitus.

机译：人体中葡萄糖动力学的长期负相关及其在糖尿病中的分解。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diurnal fluctuations in glucose levels continuously monitored during normal daily life are investigated using an extended random walk analysis, referred to as detrended fluctuation analysis (DFA), in 12 nondiabetic subjects and 15 diabetic patients. The DFA exponent alpha = 1.25 +/- 0.29 for healthy individuals in the "long-range" (>2 h) regime is shown to be significantly (P < 0.01) smaller than the reference "uncorrelated" value of alpha = 1.5, suggesting that the instantaneous net effects of the dynamical balance of glucose flux and reflux, causing temporal changes in glucose concentration, are long-range negatively correlated. By contrast, in diabetic patients, the DFA exponent alpha = 1.65 +/- 0.30 is significantly (P < 0.05) higher than that in nondiabetic subjects, evidencing a breakdown of the long-range negative correlation. It is suggested that the emergence of such positive long-range glucose correlations in diabetic patients-indicating that the net effects of the flux and reflux persist formany hours-likely reflects pathogenic mechanisms of diabetes, i.e., the lack of long-term stability of blood glucose and that the long-range negatively correlated glucose dynamics are functional in maintaining normal glucose homeostasis.
机译：在12名非糖尿病患者和15名糖尿病患者中，使用扩展的随机游动分析（称为去趋势波动分析（DFA））调查了在正常日常生活中连续监测的葡萄糖水平的每日波动。在“远程”（> 2 h）方案中，健康个体的DFA指数alpha = 1.25 +/- 0.29，被证明显着（P <0.01）比参考“无关”α= 1.5小（P <0.01）。葡萄糖通量和反流动态平衡的瞬时净效应（导致葡萄糖浓度随时间变化）与远程负相关。相比之下，在糖尿病患者中，DFA指数α= 1.65 +/- 0.30显着（P <0.05）高于非糖尿病患者，表明长期负相关性破裂。建议在糖尿病患者中出现这种长期的长期葡萄糖相关性，这表明通量和反流的净效应持续任何小时都可能反映了糖尿病的致病机制，即血液缺乏长期稳定性葡萄糖和长期负相关的葡萄糖动力学在维持正常的葡萄糖稳态中起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号