• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Scaling of diastolic intraventricular pressure gradients is related to filling time duration.
【24h】

Scaling of diastolic intraventricular pressure gradients is related to filling time duration.

机译：舒张期心室内压梯度的缩放与充盈持续时间有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In early diastole, pressure is lower in the apex than in the base of the left ventricle (LV). This early intraventricular pressure difference (IVPD) facilitates LV filling. We assessed how LV diastolic IVPD and intraventricular pressure gradient (IVPG), defined as IVPD divided by length, scale to the heart size and other physiological variables. We studied 10 mice, 10 rats, 5 rabbits, 12 dogs, and 21 humans by echocardiography. Color Doppler M-mode data were postprocessed to reconstruct IVPD and IVPG. Normalized LV filling time was calculated by dividing filling time by RR interval. The relationship between IVPD, IVPG, normalized LV filling time, and LV end-diastolic volume (or mass) as fit to the general scaling equation Y = kM beta, where M is LV heart size parameter, Y is a dependent variable, k is a constant, and beta is the power of the scaling exponent. LV mass varied from 0.049 to 194 g, whereas end-diastolic volume varied from 0.011 to 149 ml. The beta values relating normalized LV filling timewith LV mass and end-diastolic volume were 0.091 (SD 0.011) and 0.083 (SD 0.009), respectively (P < 0.0001 vs. 0 for both). The beta values relating IVPD with LV mass and end-diastolic volume were similarly significant at 0.271 (SD 0.039) and 0.243 (SD 0.0361), respectively (P < 0.0001 vs. 0 for both). Finally, beta values relating IVPG with LV mass and end-diastolic volume were -0.118 (SD 0.013) and -0.104 (SD 0.011), respectively (P < 0.0001 vs. 0 for both). As a result, there was an inverse relationship between IVPG and normalized LV filling time (r = -0.65, P < 0.001). We conclude that IVPD decrease, while IVPG increase with decreasing animal size. High IVPG in small mammals may be an adaptive mechanism to short filling times.
机译：在早期舒张期，先端的压力低于左心室（LV）的底部。这种早期的脑室内压差（IVPD）有助于左室充盈。我们评估了LV舒张期IVPD和心室内压梯度（IVPG）的定义，IVPD定义为IVPD除以长度，对心脏大小的标度和其他生理变量。我们通过超声心动图研究了10只小鼠，10只大鼠，5只兔子，12条狗和21个人。对彩色多普勒M模式数据进行后处理，以重建IVPD和IVPG。通过将填充时间除以RR间隔来计算归一化的LV填充时间。 IVPD，IVPG，标准化的左心室充盈时间和左心室舒张末期容积（或质量）之间的关系符合一般比例方程Y = kM beta，其中M为左心室大小参数，Y为因变量，k为一个常数，而beta是缩放指数的幂。左室重量从0.049到194 g不等，而舒张末期容积从0.011到149 ml不等。与标准化左室充盈时间，左室重量和舒张末期容积相关的β值分别为0.091（SD 0.011）和0.083（SD 0.009）（两者均P <0.0001 vs. 0）。 IVPD与左室重量和舒张末期容积相关的β值分别相似地分别为0.271（SD 0.039）和0.243（SD 0.0361）（P均<0.0001 vs. 0）。最后，将IVPG与左室重量和舒张末期容积相关的β值分别为-0.118（SD 0.013）和-0.104（SD 0.011）（两者均P <0.0001 vs. 0）。结果，IVPG和标准化的LV填充时间之间存在反比关系（r = -0.65，P <0.001）。我们得出结论，IVPD降低，而IVPG随着动物体型的减小而增加。小型哺乳动物的高IVPG可能是缩短灌装时间的适应机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号