• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density.
【24h】

Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density.

机译：慢性血管紧张素II AT1受体阻滞增加大脑皮层微血管的密度。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the angiotensin II type 1 (AT1) receptor. This study investigated the effect of angiotensin receptor blockade on cerebral cortical microvessel density. Rats (6-7 wk old, n = 5-17) were instrumented with femoral arterial and venous indwelling catheters for arterial blood pressure measurement and drug administration. Rats were treated for 3 or 14 days with the AT1 receptor blocker losartan (50 mg/day in drinking water) or vehicle. Brains were sectioned and immunostained for CD31, and microvessel density was measured. Treatment with losartan for 3 or 14 days resulted in a slight decrease in mean arterial blood pressure (3 days, 92 +/- 1 mmHg; and 14 days, 99 +/- 2 mmHg) compared with vehicle (109 +/- 3 and 125 +/- 4 mmHg, respectively). A furosemide + captopril 14-day treatment group was added to control for the blood pressure change (96 +/- 3 mmHg). Microvessel density increased in groups treated with losartan for 14 days (429 +/- 13 vessels/mm2) compared with vehicle (383 +/- 11 vessels/mm2) but did not change with furosemide + captopril (364 +/- 7 vessels/mm2). Thus AT1 receptor blockade for 14 days resulted in increased cerebral microvessel density in a blood pressure-independent manner.
机译：已知血管紧张素II通过激活1型血管紧张素II（AT1）受体来刺激外周循环中的血管生成。这项研究调查了血管紧张素受体阻滞对大脑皮层微血管密度的影响。给大鼠（6-7周龄，n = 5-17）装上股动脉和静脉留置导管，以测量动脉血压和给药。用AT1受体阻滞剂氯沙坦（50毫克/天，在饮用水中）或溶媒治疗大鼠3或14天。将脑切成薄片并对CD31免疫染色，并测量微血管密度。与溶媒（109 +/- 3和14 d）相比，氯沙坦治疗3或14天导致平均动脉血压略有下降（3天，92 +/- 1 mmHg; 14天，99 +/- 2 mmHg）。分别为125 +/- 4毫米汞柱）。加入速尿+卡托普利14天治疗组以控制血压变化（96 +/- 3 mmHg）。与媒介物（383 +/- 11血管/ mm2）相比，氯沙坦治疗14天的组中微血管密度增加（429 +/- 13血管/ mm2），但速尿+卡托普利（364 +/- 7血管/ mm）则无变化平方毫米）。因此，AT1受体阻滞14天导致血压依赖性的脑微血管密度增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号