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首页> 外文期刊>American Journal of Physiology >Alveoli increase in number but not size from birth to adulthood in rhesus monkeys.
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Alveoli increase in number but not size from birth to adulthood in rhesus monkeys.

机译：在恒河猴中，从出生到成年，肺泡的数量增加，但大小没有增加。

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Postnatal developmental stages of lung parenchyma in rhesus monkeys is about one-third that of humans. Alveoli in humans are reported to be formed up to 8 yr of age. We used design-based stereological methods to estimate the number of alveoli (N(alv)) in male and female rhesus monkeys over the first 7 yr of life. Twenty-six rhesus monkeys (13 males ranging in age from 4 to 1,920 days and lung volumes from 41.7 to 602 cm(3), 13 females ranging in age from 22 to 2,675 days and lung volumes from 43.5 to 380 cm(3)) were necropsied and lungs fixed, isotropically oriented, fractionated, sampled, embedded, and sectioned for alveolar counting. Parenchymal, alveolar, alveolar duct core air, and interalveolar septal tissue volumes increased rapidly during the first 2 yr with slowed growth from 2 to 7 yr. The rate of change was greater in males than females. N(alv) also showed consistent growth throughout the study, with increases in N(alv) best predicted by increases in lung volume. However, mean alveolar volumeshowed little relationship with age, lung volume, or body weight but was larger in females and showed a greater size distribution than in males. Alveoli increase in number but not volume throughout postnatal development in rhesus monkeys.
机译：恒河猴的肺实质的产后发育阶段约为人类的三分之一。据报道，人类肺泡的形成年龄高达8岁。我们使用基于设计的立体学方法来估计生命的前7年中雄性和雌性恒河猴的肺泡（N（alv））数量。 26只恒河猴（13只雄性，年龄从4到1,920天，肺活量从41.7到602 cm（3），13只雌性，年龄在22到2,675天，肺活量从43.5到380 cm（3））进行尸检并固定肺，各向同性，分级，取样，包埋和切片以进行肺泡计数。在最初的2年中，实质，肺泡，肺泡管核心空气和肺泡间隔组织的体积迅速增加，而从2到7年的生长缓慢。男性的变化率大于女性。在整个研究过程中，N（alv）也显示出持续的增长，其中N（alv）的增加最好通过肺体积的增加来预测。但是，平均肺泡容量与年龄，肺活量或体重关系不大，但女性较大，且大小分布比男性大。在猕猴的整个产后发育过程中，肺泡的数量增加，但体积没有增加。

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