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首页> 外文期刊>American Journal of Physiology >Morphometry of the extremely thin pulmonary blood-gas barrier in the chicken lung.
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Morphometry of the extremely thin pulmonary blood-gas barrier in the chicken lung.

机译：鸡肺中极薄的肺血气屏障的形态。

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摘要

The gas exchanging region in the avian lung, although proportionally smaller than that of the mammalian lung, efficiently manages respiration to meet the high energetic requirements of flapping flight. Gas exchange in the bird lung is enhanced, in part, by an extremely thin blood-gas barrier (BGB). We measured the arithmetic mean thickness of the different components (endothelium, interstitium, and epithelium) of the BGB in the domestic chicken lung and compared the results with three mammals. Morphometric analysis showed that the total BGB of the chicken lung was significantly thinner than that of the rabbit, dog, and horse (54, 66, and 70% thinner, respectively) and that all layers of the BGB were significantly thinner in the chicken compared with the mammals. The interstitial layer was strikingly thin in the chicken lung ( approximately 86% thinner than the dog and horse, and 75% thinner than rabbit) which is a paradox because the strength of the BGB is believed to come from the interstitium. In addition, the thickness of the interstitium was remarkably uniform, unlike the mammalian interstitium. The uniformity of the interstitial layer in the chicken is attributable to a lack of the supportive type I collagen cable that is found in mammalian alveolar lungs. We propose that the surrounding air capillaries provide additional structural support for the pulmonary capillaries in the bird lung, thus allowing the barrier to be both very thin and extremely uniform. The net result is to improve gas exchanging efficiency.
机译：禽肺中的气体交换区域虽然比哺乳动物的肺成比例地小，但可以有效地控制呼吸，以满足扑翼飞行的高能量需求。极薄的血气屏障（BGB）可以部分增强鸟肺中的气体交换。我们测量了家鸡肺中BGB不同成分（内皮，间质和上皮）的算术平均厚度，并将结果与​​三种哺乳动物进行了比较。形态分析表明，鸡肺的总BGB明显比兔子，狗和马的薄，分别减少了54％，66％和70％，并且与鸡相比，BGB的所有层都明显更薄与哺乳动物。鸡肺中的间质层非常薄（比狗和马薄约86％，比兔子薄约75％），这是自相矛盾的，因为人们认为BGB的强度来自间质。另外，与哺乳动物间质不同，间质的厚度非常均匀。鸡中的间质层均匀性是由于缺乏在哺乳动物的肺泡肺中发现的I型支持胶原蛋白电缆所致。我们建议周围的空气毛细管为禽肺中的肺毛细血管提供额外的结构支撑，从而使屏障非常薄且非常均匀。最终结果是提高了气体交换效率。

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