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首页> 外文期刊>American Journal of Physiology >High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion.
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High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion.

机译：高潮气量通气引起肝脏缺血再灌注后肺损伤。

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摘要

Ischemia-reperfusion not only damages the affected organ but also leads to remote organ injuries. Hepatic inflow interruption usually occurs during hepatic surgery. To investigate the influence of liver ischemia-reperfusion on lung injury and to determine the contribution of tidal volume settings on liver ischemia-reperfusion-induced lung injury, we studied anesthetized and mechanically ventilated rats in which the hepatic inflow was transiently interrupted twice for 15 min. Two tidal volumes, 6 ml/kg as a low tidal volume (IR-LT) and 24 ml/kg as a high tidal volume (IR-HT), were assessed after liver ischemia-reperfusion, as well as after a sham operation, 6 ml/kg (NC-LT) and 24 ml/kg (NC-HT). Both the IR-HT and IR-LT groups had a gradual decline in the systemic blood pressure and a significant increase in plasma TNF-alpha concentrations. Of the four groups, only the IR-HT group developed lung injury, as assessed by an increase in the lung wet-to-dry weight ratio, the presence of significant histopathological changes, such as perivascular edema and intravascular leukocyte aggregation, and an increase in the bronchoalveolar lavage fluid TNF-alpha concentration. Furthermore, only in the IR-HT group was airway pressure increased significantly during the 6-h reperfusion period. These findings suggest that liver ischemia-reperfusion caused systemic inflammation and that lung injury is triggered when high tidal volume ventilation follows liver ischemia-reperfusion.
机译：缺血-再灌注不仅损害受影响的器官，而且导致远端器官损伤。肝流入中断通常发生在肝手术期间。为了研究肝脏缺血再灌注对肺损伤的影响并确定潮气量设置对肝脏缺血再灌注诱导的肺损伤的影响，我们研究了麻醉和机械通气的大鼠，其中肝流入量被短暂中断两次，持续15分钟。在肝脏缺血再灌注后以及假手术后，评估了两个潮气量，低潮气量为6 ml / kg（IR-LT），高潮气量为24 ml / kg（IR-HT）， 6毫升/千克（NC-LT）和24毫升/千克（NC-HT）。 IR-HT和IR-LT组的全身血压均逐渐下降，血浆TNF-α浓度显着升高。在这四组中，只有IR-HT组出现肺损伤，这通过肺干重比的增加，明显的组织病理学改变（例如血管周围水肿和血管内白细胞聚集）以及增加而评估支气管肺泡灌洗液中TNF-α的浓度。此外，仅IR-HT组在6小时的再灌注期间气道压力显着增加。这些发现表明，肝脏缺血再灌注会引起全身性炎症，并且在肝脏缺血再灌注后高潮气量通气时会触发肺损伤。

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