Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation

Amanda J. Zatta; Hajime Kin; Darice Yoshishige; Rong Jiang; Ningping Wang; James G. Reeves

首页> 外文期刊>American Journal of Physiology >Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation

【24h】

Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation

机译：后处理对心脏的保护作用涉及保留心肌阿片样物质含量和选择性阿片样物质受体激活的证据

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Opioids are well-known endogenous triggers of preconditioning and were recently determined to be effective at reducing infarct size when given at reperfusion through interaction with their cognate G protein-coupled receptors (4, 11-14, 40). Therefore, in light of these reports, the following study tested the hypothesis that the infarct-sparing effects of postconditioning involve endogenous activation of opioid receptors. A series of dose responses were performed with a variety of nonselec-tive and subtype-selective opioid receptor antagonists to determine whether the response might be preferentially mediated by one or more opioid receptor subtypes [(x (MOR)-, 8 (DOR)-, and k (KOR)-opioid receptors].

机译：阿片类药物是众所周知的内源性预处理触发剂，最近被确定可通过与它们的相关G蛋白偶联受体相互作用而在再灌注时有效减少梗塞面积（4、11-14、40）。因此，根据这些报告，以下研究检验了以下假设：后处理的梗塞保护作用涉及阿片受体的内源性激活。使用多种非选择性和亚型选择性阿片受体拮抗剂进行了一系列剂量反应，以确定该反应是否可能优先受一种或多种阿片受体亚型[（x（MOR）-，8（DOR）-和k（KOR）阿片受体]。

著录项

来源
《American Journal of Physiology》 |2008年第2期|共8页
作者
Amanda J. Zatta; Hajime Kin; Darice Yoshishige; Rong Jiang; Ningping Wang; James G. Reeves;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation [J] . Amanda J. Zatta, Hajime Kin, Darice Yoshishige, American Journal of Physiology . 2008,第3aPta2期

机译：后处理对心脏的保护作用涉及保留心肌阿片样物质含量和选择性阿片样物质受体激活的证据
2. Differential Effects of Anesthetics and Opioid Receptor Activation on Cardioprotection Elicited by Reactive Oxygen Species-Mediated Postconditioning in Sprague-Dawley Rat Hearts [J] . Lucchinetti Eliana, Lou Phing-How, Gandhi Manoj, Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2018,第5期

机译：麻醉剂和阿片类受体激活对Shrague-Dawley大鼠心脏反应性氧物种引发的心脏保护作用的差异影响
3. Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance [J] . Sarah V Holdridge, Stacey A Armstrong, Anna MW Taylor, Molecular pain . 2007,第2期

机译：胶质细胞激活参与δ阿片受体功能的行为和形态学证据：对阿片耐受性发展的影响
4. Opioid Ligand Binding to Opioid Receptors: Insight and Implications for Peptide Design [C] . Michael J. Ferracane, Jane V. Aldrich American Peptide Symposium . 2015

机译：阿片类配体与阿片受体的结合：肽设计的见解和影响
5. Mechanistic comparison of the signal transduction pathways responsible for cardioprotection induced by myocardial preconditioning or stimulation of the delta-one-opioid receptor. [D] . Fryer, Ryan Michael. 2001

机译：负责心肌预处理或刺激δ一阿片样物质受体引起的心脏保护的信号转导途径的机制比较。
6. Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and d-Ala2-MePhe4-Glyol5Enkephalin as Selective μ−δ Agonists [O] . Ajay S. Yekkirala, Alexander E. Kalyuzhny, Philip S. Portoghese, 2010

机译：标准阿片类激动剂激活异源阿片受体：吗啡和d-Ala2-MePhe4-甘醇5脑啡肽作为选择性μ-δ激动剂的证据。
7. Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance [O] . Taylor Anna MW, Armstrong Stacey A, Holdridge Sarah V, 2007

机译：胶质细胞激活参与δ阿片受体功能的行为和形态学证据：对阿片耐受性发展的影响
8. Endogenous Opioids and Their Receptors. Evidence for Involvement in the Postictal Effects of Electroconvulsive Shock. Part 3. Biochemical and Neuroendocrinological Effects 2 [R] . Holaday, J. W., Tortella, F. C., Long, J. B., 1985

机译：内源性阿片类药物及其受体。参与电惊厥后发效应的证据。第3部分。生化和神经内分泌学的影响2

Evidence that cardioprotection by postconditioning involves preservation of myocardial opioid content and selective opioid receptor activation

摘要

著录项

相似文献

相关主题

期刊订阅