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首页> 外文期刊>American Journal of Physiology >Effects of ghrelin administration on decreased growth hormone status in obese animals.
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Effects of ghrelin administration on decreased growth hormone status in obese animals.

机译：生长激素释放肽的施用对肥胖动物生长激素状态降低的影响。

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Obesity is characterized by markedly decreased ghrelin and growth hormone (GH) secretion. Ghrelin is a GH-stimulating, stomach-derived peptide that also has orexigenic action. Ghrelin supplement may restore decreased GH secretion in obesity, but it may worsen obesity by its orexigenic action. To reveal effects of ghrelin administration on obese animals, we first examined acute GH and orexigenic responses to ghrelin in three different obese and/or diabetic mouse models: db/db mice, mice on a high-fat diet (HFD mice), and Akita mice for comparison. GH responses to ghrelin were significantly suppressed in db/db, HFD, and Akita mice. Food intake of db/db and Akita mice were basally higher, and further stimulation of food intake by ghrelin was suppressed. Pituitary GH secretagogue receptor mRNA levels in db/db and HFD mice were significantly decreased, which may partly contribute to decreased GH response to ghrelin in these mice. In Akita mice for comparison, decreased hypothalamic GH-releasing hormone (GHRH) mRNA levels may be responsible for decreased GH response, since maximum GH response to ghrelin needs GHRH. When ghrelin was injected into HFD mice with GHRH coadministrated, GH responses to ghrelin were significantly emphasized. HFD mice injected with low-dose ghrelin and GHRH for 10 days did not show weight gain. These results indicate that low-dose ghrelin and GHRH treatment may restore decreased GH secretion in obesity without worsening obesity.
机译：肥胖症的特征是生长素释放肽和生长激素（GH）分泌明显减少。 Ghrelin是一种刺激胃的GH肽，也具有致癌作用。 Ghrelin补充剂可恢复肥胖症中GH分泌的减少，但由于其致食作用可能会使肥胖症恶化。为了揭示生长激素释放肽对肥胖动物的影响，我们首先在三种不同的肥胖和/或糖尿病小鼠模型中检查了急性生长激素和对生长激素释放肽的致敏反应：db / db小鼠，高脂饮食小鼠（HFD小鼠）和秋田小鼠进行比较。在db / db，HFD和秋田小鼠中，GH对生长激素释放肽的反应被显着抑制。 db / db和秋田小鼠的食物摄入量基本较高，并且生长素释放肽对食物摄入量的进一步刺激被抑制。 db / db和HFD小鼠的垂体GH促分泌素受体mRNA水平显着降低，这可能部分导致这些小鼠对ghrelin的GH反应降低。在用于比较的秋田小鼠中，下丘脑GH释放激素（GHRH）mRNA水平下降可能是导致GH反应下降的原因，因为对ghrelin的最大GH反应需要GHRH。当将生长素释放肽注射到与GHRH并用的HFD小鼠中时，将显着强调GH对生长素释放肽的反应。注射低剂量生长激素释放肽和GHRH 10天的HFD小鼠未显示体重增加。这些结果表明，低剂量的生长激素释放肽和GHRH治疗可恢复肥胖症中GH分泌减少，而不会恶化肥胖症。

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