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首页> 外文期刊>American Journal of Physiology >Chemical ablation of the Purkinje system causes early termination activation rate slowing of long-duration ventricular fibrillation in dogs
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Chemical ablation of the Purkinje system causes early termination activation rate slowing of long-duration ventricular fibrillation in dogs

机译：Purkinje系统的化学消融可导致犬长期持续性心室纤颤的早期终止活化率减慢

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摘要

Endocardial mapping has suggested that Purkinje fibers may play a role in the maintenance of long-duration ventricular fibrillation (LDVF). To determine the influence of Purkinje fibers on LDVF, we chemically ablated the Purkinje system with Lugol solution and recorded endocardial and transmural activation during LDVF. Dog hearts were isolated and perfused, and the ventricular endocardium was exposed and treated with Lugol solution (n = 6) or normal Tyrode solution as a control (n - 6). The left anterior papillary muscle endocardium was mapped with a 504-electrode (21 X 24) plaque with electrodes spaced 1 mm apart. Transmural activation was recorded with a six-electrode plunge needle on each side of the plaque. Ventricular fibrillation (VF) was mduced, and perfusion was halted. LDVF spontaneously terminated sooner in Lugol-ablated hearts than in control hearts (4.9 +- 1.5 vs. 9.2 +- 3.2 min, P = 0.01). After termination of VF, both the control and Lugol hearts were typically excitable, but only short episodes of VF could be reinduced. Endocardial activation rates were similar during the first 2 min of LDVF for Lugol-ablated and control hearts but were significantly slower in Lugol hearts by 3 min. In control hearts, the endocardium activated more rapidly than the epicardium after 4 min of LDVF with wave fronts propagating most often from the endocardium to epicardium. No difference in transmural activation rate or wave front direction was observed in Lugol hearts. Ablation of the subendocardium hastens VF spontaneous termination and alters VF activation sequences, suggesting that Purkinje fibers are important in the maintenance of LDVF.
机译：心内膜定位提示浦肯野纤维可能在维持长期心室纤颤（LDVF）中发挥作用。为了确定浦肯野纤维对LDVF的影响，我们用Lugol溶液化学烧蚀了浦肯野系统，并记录了LDVF期间的心内膜和透壁激活。分离并灌注狗的心脏，暴露心室心内膜并用Lugol溶液（n = 6）或以普通Tyrode溶液作为对照（n-6）进行处理。左前乳头肌心内膜标有504电极（21 X 24）斑块，电极间隔为1 mm。在斑块的每一侧用六电极刺入针记录透壁激活。诱发室颤（VF），并停止灌注。在Lugol消融的心脏中，LDVF自发终止的时间要快于对照心脏（4.9±1.5和9.2±3.2分钟，P = 0.01）。 VF终止后，对照组和Lugol心脏通常均可兴奋，但只能诱发短时间的VF发作。对于Lugol消融和对照心脏，LDVF的前2分钟内心内膜激活率相似，但在3分钟后，Lugol心脏中的心内膜激活率显着降低。在对照心脏中，LDVF 4分钟后，心内膜的活化比心外膜活化更快，并且波前最常从心内膜向心外膜传播。在Lugol心脏中未观察到透壁激活率或波前方向的差异。心内膜下层的切除会加速VF的自发终止并改变VF的激活序列，这表明浦肯野纤维在LDVF的维持中很重要。

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