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首页> 外文期刊>American Journal of Physiology >Lower capacitance response and capillary fluid absorption in women to defend central blood volume in response to acute hypovolemic birculatory stress
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Lower capacitance response and capillary fluid absorption in women to defend central blood volume in response to acute hypovolemic birculatory stress

机译：降低女性的电容反应和毛细血管液吸收，以防御急性低血容量性呼吸压力，从而保护中央血容量

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摘要

Acute hemorrhage is a leadingcause of death in trauma, and women are more susceptible to hypovolemic circulatory stress than men. The mechanisms underlying the susceptibility are not clear, however. The aim of the present study was to examine the compensatory mechanisms to defend central blood volume during experimental hypovolemia in women and men. Twenty-two women (23.1 +- 0.4 yr) and 16 men (23.2 +- 0.5 yr) were included. A lower body negative pressure (LBNP) of 11-44 mmHg induced experimental hypovolemic circulatory stress. The volumetric technique was used to assess the capacitance response (redistribution of peripheral venous blood to the central circulation) as well as to assess net capillary fluid transfer from tissue to blood in the arm. Plasma norepinephrine (NE) and forearm blood flow were measured before and during hypovolemia, and forearm vascular resistance (FVR) was calculated. LBNP created comparable hypovolemia in women and men FVR increased less in women during hypovolemic stress, and no association between plasma NE and FVR was seen in women (Rz = .0.01, not significant), in contrast to men (Rz = 0.59, P < 0.05). Women demonstrated a good initial capacitance response, but this was not maintained with time, in contrast to men [e.g., decreased by 24 +- 4% (women) vs. 4 +- 5% (men), LBNP of 44 mmHg, P < 0.01], and net capillary fluid absorption from tissue to blood was lower in women (0.086 +- 0.007 vs. 0.115 +- 0.011 ml-100 ml~(-1) min~(-1), P < 0.05). In conclusion, women showed impaired vasoconstriction, reduced capacitance response with time, and reduced capillary fluid absorption during acute hypovolemic circulatory stress, indicating less efficiency to defend central blood volume than men.
机译：急性出血是造成外伤死亡的主要原因，与男性相比，女性更容易发生低血容量循环应激。但是，易感性的潜在机制尚不清楚。本研究的目的是研究在男性和女性实验性血容量不足时捍卫中央血容量的补偿机制。其中包括22名女性（23.1±0.4岁）和16名男性（23.2±0.5岁）。下体负压（LBNP）为11-44 mmHg，诱发实验性低血容量循环应激。容积技术用于评估电容响应（外周静脉血液向中央循环的重新分配），以及评估从组织到手臂中血液的净毛细血管转移。在血容量不足之前和期间测量血浆去甲肾上腺素（NE）和前臂血流量，并计算前臂血管阻力（FVR）。 LBNP在男性和女性中产生相当的血容量不足，在低血容量压力下女性的FVR增加较少，女性与血浆NE和FVR之间没有关联（Rz = .0.01，不显着），与男性相比（Rz = 0.59，P < 0.05）。与男性相比，女性表现出了良好的初始电容响应，但随着时间的推移并没有得到维持[例如，女性降低了24±4％（男性），男性降低了4±5％（男性），LBNP为44 mmHg，P <0.01]，女性从组织到血液的净毛细血管液吸收较低（0.086±0.007 vs. 0.115±0.011 ml-100 ml〜（-1）min〜（-1），P <0.05）。总之，在急性低血容量循环应激过程中，女性表现出血管收缩受损，电容响应随时间降低，毛细血管吸收减少，这表明男性在保护中央血容量方面的效率低于男性。

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