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Role of caveolin~(-1) in regulation of inflammation: different strokes for different folks

机译:Caveolin〜(-1)在炎症调节中的作用:针对不同人群的不同中风

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the article by hu et al. (10) describes a novel role for caveolin~(-1) in regulating antimicrobial responses of neutrophils as well as inflammatory lung injury. Previous reports had documented expression of caveolin~(-1) in immune cells (9), including professional phagocytes such as neutrophils (38), but its functional role was not well understood. Hu et al. provide compelling evidence for the pivotal role of caveolin~(-1) in regulating neutrophil functional responses that underpin innate immunity. How then does caveolin~(-1), a ubiquitously expressed protein with well-recognized roles in protein and cholesterol trafficking in endothelial cells and in tumor suppression, modulate the activation of these itinerant leukocytes? To understand this, it is important to review our current understanding of the functions of caveolae and caveolins.
机译:hu等人的文章。 (10)描述了小窝蛋白(-1)在调节中性粒细胞的抗菌反应以及炎性肺损伤中的新作用。先前的报道已经证明了caveolin〜(-1)在免疫细胞(9)中的表达,包括专业吞噬细胞(如中性粒细胞)(38),但其功能作用尚不十分清楚。 Hu等。提供了令人信服的证据证明小窝蛋白〜(-1)在调节增强先天免疫力的中性粒细胞功能性反应中的关键作用。那么,在血管内皮细胞中的蛋白质和胆固醇运输中以及在肿瘤抑制中广为人知的作用的普遍表达的蛋白质caveolin〜(-1)如何调节这些流动性白细胞的激活?要了解这一点,重要的是回顾我们对小窝和小窝蛋白功能的当前理解。

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