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首页> 外文期刊>American Journal of Physiology >Edelman's equation is valid in acute hyponatremia in a porcine model: plasma sodium concentration is determined by external balances of water and cations.
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Edelman's equation is valid in acute hyponatremia in a porcine model: plasma sodium concentration is determined by external balances of water and cations.

机译：埃德曼方程在猪模型的急性低钠血症中有效：血浆钠浓度由水和阳离子的外部平衡决定。

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Acute hyponatremia is a serious condition, which poses major challenges. Of particular importance is what determines plasma sodium concentration ([Na(+)]). Edelman introduced an explicit model to describe plasma [Na(+)] in a population as [Na(+)] = alpha.(exchangeable Na(+) + exchangeable K(+))/(total body water) - beta. Evidence for the clinical utility of the model in the individual and in acute hyponatremia is sparse. We, therefore, investigated how the measured plasma [Na(+)] could be predicted in a porcine model of hyponatremia. Plasma [Na(+)] was estimated from in vivo-determined balances of water, Na(+), and K(+), according to Edelman's equation. Acute hyponatremia was induced with desmopressin acetate and infusion of a 2.5% glucose solution in anesthetized pigs. During 480 min, plasma [Na(+)] and osmolality were reduced from 136 (SD 2) to 120 mmol/l (SD 3) and from 284 (SD 4) to 252 mosmol/kgH(2)O (SD 5), respectively. The following interpretations were made. First, Edelman's model, which, besides dilution, takes into account Na(+) and K(+), fits plasma [Na(+)] significantly better than dilution alone. Second, a common value of alpha = 1.33 (SD 0.08) and beta = -13.04 mmol/l (SD 7.68) for all pigs explains well the plasma [Na(+)] in the individual animal. Third, measured exchangeable Na(+) and calculated exchangeable Na(+) + K(+) per weight in the pigs are close to Edelman's findings in humans, whereby the methods are cross-validated. In conclusion, plasma [Na(+)] can be explained in the individual animal by external balances, according to Edelman's construct in acute hyponatremia.
机译：急性低钠血症是一种严重的疾病，这构成了重大挑战。决定血浆钠浓度（[Na（+）]）的因素尤为重要。 Edelman引入了一个显式模型来描述人群中的血浆[Na（+）]为[Na（+）] =α。（可交换Na（+）+可交换K（+））/（全身水）-beta。该模型在个体和急性低钠血症中的临床应用证据很少。因此，我们研究了如何在低钠血症猪模型中预测血浆[Na（+）]。根据体内确定的水，Na（+）和K（+）的平衡，根据埃德曼方程估算血浆[Na（+）]。醋酸去氨加压素和在麻醉猪中注入2.5％葡萄糖溶液可诱发急性低钠血症。在480分钟内，血浆[Na（+）]和重量摩尔渗透压浓度从136（SD 2）降至120 mmol / l（SD 3），从284（SD 4）降至252 mosmol / kgH（2）O（SD 5） ， 分别。作出以下解释。首先，除了稀释之外，Edelman模型还考虑了Na（+）和K（+），比单独使用稀释液更好地拟合血浆[Na（+）]。其次，所有猪的共同值α= 1.33（SD 0.08）和β= -13.04 mmol / l（SD 7.68）很好地解释了个体动物的血浆[Na（+）]。第三，在猪中测得的每单位重量的可交换Na（+）和计算出的可交换Na（+）+ K（+）与Edelman在人类身上的发现相近，因此该方法得到了交叉验证。总之，根据爱德曼在急性低钠血症中的构造，血浆[Na（+）]可以通过外部平衡解释在单个动物中。

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