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首页> 外文期刊>American Journal of Physiology >A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans.
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A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans.

机译：对成年人棕色脂肪组织的患病率和代谢意义的重要评估。

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Brown adipose tissue (BAT) plays a major role in energy homeostasis in animals. Detection of BAT using positron emission tomography (PET)-CT in humans has challenged the view that BAT disappears after infancy. Several recent studies, based on analysis of single scans, have reported a low prevalence of only 5-10% in humans, casting doubt on its significance. We undertook a critical analysis of the sensitivity, reproducibility, and accuracy of PET-CT to deduce the prevalence of BAT and factors associated with its detection in adult humans. In a retrospective evaluation of PET-CT, using [18F]fluorodeoxyglucose, performed in 2,934 patients, BAT was identified in 250 patients, yielding an apparent prevalence of 8.5%. Among those patients with BAT, 145 were scanned more than once. The frequency of another scan being positive increased from 8 to 65% for one to more than four additional studies. The average probability of obtaining another positive scan among patients with BAT is 13%, from which the prevalence of BAT is estimated at 64%. BAT was more commonly detected in women, in younger (36 +/- 1 vs. 52 +/- 1 years, P < 0.001) and leaner (20.1 +/- 0.9 vs. 24.9 +/- 0.9 kg/m2, P < 0.01) individuals. Fasting glucose was lower in those with BAT than those without (4.9 +/- 0.1 vs. 5.5 +/- 0.1 mmol/l, P < 0.01). Among patients scanned more than once, BAT was detected when body weight and fasting glucose were lower (54.9 +/- 0.5 vs. 58.2 +/- 0.8 kg, P < 0.001 and 4.9 +/- 0.3 vs. 5.5 +/- 0.3 mmol/l, P = 0.03). We conclude that BAT is present in the majority of adult humans. Presence of BAT correlates negatively with body mass index and glucose concentration. BAT may play an important role in energy homeostasis in adults.
机译：棕色脂肪组织（BAT）在动物体内能量稳态中起主要作用。使用正电子发射断层扫描（PET）-CT在人体中检测BAT已挑战了婴儿期后BAT消失的观点。基于单次扫描的分析，最近的几项研究报告了人类中的低患病率，仅为5-10％，这对其重要性表示怀疑。我们对PET-CT的敏感性，可重复性和准确性进行了批判性分析，以推论BAT的患病率及其在成人中的检测相关因素。在对2934名患者使用[18F]氟脱氧葡萄糖进行PET-CT的回顾性评估中，在250名患者中发现了BAT，表观患病率为8.5％。在那些患有BAT的患者中，有145多次被扫描。一项额外的一项研究中，另一项扫描呈阳性的频率从8％上升至65％。 BAT患者获得另一次阳性扫描的平均概率为13％，据估计BAT患病率为64％。 BAT更常见于女性，年轻（36 +/- 1 vs. 52 +/- 1岁，P <0.001）和更瘦（20.1 +/- 0.9 vs. 24.9 +/- 0.9 kg / m2，P < 0.01）个人。有BAT者的空腹血糖低于无BAT者（4.9 +/- 0.1与5.5 +/- 0.1 mmol / l，P <0.01）。在多次扫描的患者中，当体重和空腹血糖降低时，检测到了BAT（54.9 +/- 0.5 vs. 58.2 +/- 0.8 kg，P <0.001和4.9 +/- 0.3 vs. 5.5 +/- 0.3 mmol / l，P = 0.03）。我们得出的结论是，大多数成年人中都存在BAT。 BAT的存在与体重指数和葡萄糖浓度呈负相关。 BAT在成人的能量稳态中可能起重要作用。

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