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首页> 外文期刊>American Journal of Physiology >Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide.
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Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide.

机译：昼夜调节心血管功能：血管活性肠肽的作用。

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摘要

The circadian system, driven by the suprachiasmatic nucleus (SCN), regulates properties of cardiovascular function. The dysfunction of this timing system can result in cardiac pathology. The neuropeptide vasoactive intestinal peptide (VIP) is crucial for circadian rhythms in a number of biological processes including SCN electrical activity and wheel running behavior. Anatomic evidence indicates that SCN neurons expressing VIP are well positioned to drive circadian regulation of cardiac function through interactions with the autonomic centers. In this study, we tested the hypothesis that loss of VIP would result in circadian deficits in heart rate (HR) and clock gene expression in cardiac tissue. We implanted radiotelemetry devices into VIP-deficient mice and wild-type (WT) controls and continuously recorded HR, body temperature, and cage activity in freely moving mice. Under light-dark conditions, VIP-deficient mice displayed weak rhythms in HR, body temperature, and cage activity, with onsets that were advanced in phase compared with WT mice. Similarly, clock gene expression in cardiac tissue was rhythmic but phase advanced in mutant mice. In constant darkness, the normal circadian rhythms in HR were lost in VIP-deficient mice; however, most mutant mice continued to exhibit circadian rhythms of body temperature with shortened free-running period. The loss of VIP altered, but did not abolish, autonomic regulation of HR. Analysis of the echocardiograms did not find any evidence for a loss of cardiac function in VIP-deficient mice, and the size of the hearts did not differ between genotypes. These results demonstrate that VIP is an important regulator of physiological circadian rhythmicity in the heart.
机译：由视交叉上核（SCN）驱动的昼夜节律系统调节心血管功能的特性。该计时系统的功能障碍可能导致心脏病理。神经肽血管活性肠肽（VIP）对于许多生物过程（包括SCN电活动和车轮行驶行为）的昼夜节律至关重要。解剖学证据表明，表达VIP的SCN神经元位置优越，可通过与自主中心的相互作用来驱动心脏功能的昼夜节律调节。在这项研究中，我们检验了VIP丢失会导致心脏组织中的心律（HR）和时钟基因表达的昼夜节律缺陷的假设。我们将无线电遥测设备植入VIP缺陷小鼠和野生型（WT）对照中，并连续记录自由移动小鼠的HR，体温和笼活动。在光暗条件下，VIP缺乏的小鼠在HR，体温和笼活动方面表现出较弱的节律，与WT小鼠相比，其发作提前。同样，心脏组织中Clock基因的表达是有节奏的，但突变小鼠的相位却提前。在持续的黑暗中，VIP缺陷小鼠的HR昼夜节律失调。然而，大多数突变小鼠继续表现出昼夜节律的体温和缩短的自由运行时间。 VIP的丧失改变了HR的自主调节能力，但并未消除。超声心动图的分析未发现任何证据表明VIP缺陷小鼠的心脏功能丧失，并且基因型之间的心脏大小没有差异。这些结果表明，VIP是心脏生理昼夜节律的重要调节器。

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