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首页> 外文期刊>Cortex: A Journal Devoted to the Study of the Nervous System and Behavior >Susceptibility weighted imaging and its relationship to outcome after pediatric traumatic brain injury
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Susceptibility weighted imaging and its relationship to outcome after pediatric traumatic brain injury

机译：小儿脑外伤后药敏加权成像及其与预后的关系

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Introduction: Traumatic brain injury (TBI) sustained during childhood can cause difficulties in a wide range of physical, neurological, cognitive, social and functional domains. However, the ability of health professionals and researchers to accurately predict the outcome of pediatric TBI remains limited. The advent of advanced neuroimaging techniques shows some promise in improving outcome prediction, as they contribute to greater sensitivity in characterizing intracranial lesions underlying many cognitive and functional deficits. In this study, the relationship between lesions identified on susceptibility weighted imaging (SWI) and cognitive and functional outcomes was investigated following childhood TBI. Method: Participants between 5 and 14 years of age with varying levels of TBI severity (mild, mild complicated, moderate, severe, n = 106) underwent susceptibility weighted scanning on average 1-month post-injury and completed an assessment of intellectual functioning, processing speed, and behavioral and adaptive skills 6-month post-injury. Results: More severe TBI was generally associated with poorer intellectual functioning, greater behavioral problems and lower adaptive functioning. Number and volume of SWI lesions were significantly correlated with clinical outcome variables including Glasgow Coma Score (GCS), surgical intervention, length of hospital stay and length of intubation, as well as with intellectual functioning. Together, SWI and GCS accounted for a significant, though small, proportion of the variance in intellectual quotient (IQ). Conclusions: SWI is a sensitive technique for detecting brain lesions at all TBI severity levels and shows promise in contributing to prediction of cognitive outcomes in the initial stages post-injury. ? 2012 Elsevier Ltd.
机译：简介：儿童时期遭受的创伤性脑损伤（TBI）可能在许多物理，神经，认知，社会和功能领域造成困难。但是，卫生专业人员和研究人员准确预测儿科TBI结局的能力仍然有限。先进的神经影像技术的出现在改善结局预测方面显示出一些希望，因为它们有助于表征许多认知和功能缺陷背后的颅内病变。在这项研究中，调查了儿童TBI后在敏感性加权成像（SWI）上识别出的病变与认知和功能结局之间的关系。方法：对5至14岁，TBI严重程度不同（轻度，轻度复杂，中度，重度，n = 106）的参与者在受伤后平均1个月进行药敏加权扫描，并完成对智力功能的评估，处理速度，以及伤后6个月的行为和适应技能。结果：较严重的TBI通常与较差的智力功能，较大的行为问题和较低的适应性功能有关。 SWI病变的数量和大小与临床结果变量（包括格拉斯哥昏迷评分（GCS），手术干预，住院时间和插管时间以及智力功能）显着相关。 SWI和GCS一起占智商（IQ）方差的很大一部分，尽管很小。结论：SWI是检测所有TBI严重程度的脑部病变的灵敏技术，显示出有望在损伤后初期预测认知结局的潜力。 ？ 2012爱思唯尔有限公司

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